Familial myelodysplastic syndrome/acute myeloid leukemia

被引：24

作者：

Churpek, Jane E. ^{[1
]}

机构：

[1] Univ Chicago Med, Sect Hematol Oncol, Canc Risk & Prevent Clin, Hereditary Hematol Malignancies Program, 5841 S Maryland Ave MC2115, Chicago, IL 60637 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2017年 / 30卷 / 04期

关键词：

Acute myeloid leukemia; AML; Inherited; Genetics; Hereditary myeloid malignancy syndromes; MDS; Myelodysplastic syndromes; Predisposition; DYSKERATOSIS-CONGENITA; APLASTIC-ANEMIA; MUTATIONS; GENES; CLASSIFICATION; HEMATOPOIESIS; PROGNOSIS; CANCER; AML; DNA;

D O I：

10.1016/j.beha.2017.10.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A growing number of inherited genetic loci that contribute to myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) development in both children as well as adults are rapidly being identified. In recognition of the clinical impact of this emerging field, the World Health Organization, National Comprehensive Cancer Network, and European LeukemiaNet have all added consideration of inherited predisposition to MDS/AML classification and management. Study of these disorders is providing unique insight into the biology of both sporadic and familial MDS/AML. International collaborative efforts to store germline tissue, document family histories, and pool data are essential to progress in diagnosing and treating both hereditary and sporadic forms of MDS/AML. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：287 / 289

页数：3

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