Antimicrobial properties of avian eggshell-specific C-type lectin-like proteins

被引：46
|
作者：
Wellman-Labadie, Olivier [1 ]
Lakshminarayanan, Rajamani [2 ]
Hincke, Maxwell T. [1 ]
机构：
[1] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada
[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
来源：
FEBS LETTERS | 2008年 / 582卷 / 05期
基金：
加拿大自然科学与工程研究理事会;
关键词：
antibiotics; antibacterial; avian eggshell; bacterial polysaccharides; C-type lectin;
D O I：
10.1016/j.febslet.2008.01.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
C-type lectin-like proteins are major components of the calcified eggshell of multiple avian species. In this study, two representative avian C-type lectin-like proteins, ovocleidin-17 and ansocalcin, were purified from decalcified chicken and goose eggshell protein extracts and investigated for carbohydrate binding activity as well as antimicrobial activity. Purified ovocleidin-17 and ansocalcin were found to bind bacterial polysaccharides, and were bactericidal against Bacillus subtilis, Staphylococcus aureus and Pseudomona aeruginosa. Bactericidal activity was found to be enhanced in the presence of calcium but was not dependent on its presence. The results suggest that avian C-type lectin-like proteins may play an important antimicrobial role in defence of the avian embryo. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：699 / 704
页数：6
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