Iron(II)-Catalyzed Asymmetric Intramolecular Aminohydroxylation of Indoles

被引：59
|
作者：
Zhang, Yong-Qiang [1 ]
Yuan, Yong-An [1 ]
Liu, Guan-Sai [1 ]
Xu, Hao [1 ]
机构：
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 15期
关键词：
ORGANOCATALYTIC ALPHA-AMINATION; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; IRON; AMINOOXYGENATION; LIGANDS; ALKENES; AZIRIDINATION; OXYAMINATION; EPOXIDATION;
D O I：
10.1021/ol401666e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective intramolecular indole aminohydroxylation reaction is catalyzed by iron(II)-chiral bisoxazoline (BOX) complexes (ee up to 99%, dr>20:1). This discovery enables expedient asymmetric synthesis of a series of biologically active 3-amino oxindoles and 3-amino indolanes.
引用
收藏
页码：3910 / 3913
页数：4
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