Iron(II)-Catalyzed Asymmetric Intramolecular Aminohydroxylation of Indoles

被引：59

作者：

Zhang, Yong-Qiang ^{[1
]}

Yuan, Yong-An ^{[1
]}

Liu, Guan-Sai ^{[1
]}

Xu, Hao ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 15期

关键词：

ORGANOCATALYTIC ALPHA-AMINATION; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; IRON; AMINOOXYGENATION; LIGANDS; ALKENES; AZIRIDINATION; OXYAMINATION; EPOXIDATION;

D O I：

10.1021/ol401666e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective intramolecular indole aminohydroxylation reaction is catalyzed by iron(II)-chiral bisoxazoline (BOX) complexes (ee up to 99%, dr>20:1). This discovery enables expedient asymmetric synthesis of a series of biologically active 3-amino oxindoles and 3-amino indolanes.

引用

页码：3910 / 3913

页数：4

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