Rett syndrome: what do we know for sure?

被引：18
|
作者：
Zoghbi, Huda Y. [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Baylor Coll Med, Howard Hughes Med Inst, Programs Cell & Mol Biol, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Baylor Coll Med, Howard Hughes Med Inst, Programs Cell & Mol Biol, Dept Neurosci, Houston, TX 77030 USA
[3] Baylor Coll Med, Howard Hughes Med Inst, Programs Cell & Mol Biol, Dept Pediat, Houston, TX 77030 USA
[4] Baylor Coll Med, Howard Hughes Med Inst, Programs Dev Biol, Dept Mol & Human Genet, Houston, TX 77030 USA
[5] Baylor Coll Med, Howard Hughes Med Inst, Programs Dev Biol, Dept Neurosci, Houston, TX 77030 USA
[6] Baylor Coll Med, Howard Hughes Med Inst, Programs Dev Biol, Dept Pediat, Houston, TX 77030 USA
来源：
NATURE NEUROSCIENCE | 2009年 / 12卷 / 03期
关键词：
MECP2; NEURONS; EXPRESSION; GLIA;
D O I：
10.1038/nn0309-239
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rett syndrome (RTT) is caused by mutations in the X-linked gene encoding methyl CpG–binding protein (MeCP2). The loss of MeCP2 function in neurons was thought to cause the disease. A study now challenges this assumption by showing that MeCP2 is expressed in glia and that MeCP2 loss in glia causes abnormalities in neighboring neurons.
引用
收藏
页码：239 / 240
页数：2
相关论文
共 50 条
12345