Interleukin-6: Possible biological roles during exercise

被引:79
作者
Reihmane, Dace [1 ]
Dela, Flemming [2 ]
机构
[1] Riga Stradins Univ, LV-1007 Riga, Latvia
[2] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark
关键词
Interleukin-6; exercise; inflammation; metabolism; HUMAN SKELETAL-MUSCLE; MESSENGER-RNA EXPRESSION; CARBOHYDRATE INGESTION; GLYCOGEN AVAILABILITY; PLASMA INTERLEUKIN-6; RECEPTOR EXPRESSION; STRENUOUS EXERCISE; CYTOKINE CHANGES; INDUCED INCREASE; MARATHON RACE;
D O I
10.1080/17461391.2013.776640
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Interleukin-6 (IL-6) is a multifunctional cytokine that exerts its modulatory effects on cells that express membrane bound IL-6 receptors; however, IL-6 in a complex with soluble IL-6R can bind to any cell that express glycoprotein 130 (gp130). Thus, all cell types may respond to the pro- as well as anti-inflammatory properties of IL-6. Since the first report of acute exercise-induced increase in plasma IL-6 in the early 1990s, scientists have tried to elucidate the factors that influence the magnitude of change of plasma IL-6, as well as the possible biological roles of this cytokine. Evidence suggests that exercise intensity and duration as well as the form of contraction (e.g. eccentric or concentric) and muscle damage all influence IL-6 response to acute exercise. However, data on training status and performance on plasma IL-6 concentration changes during exercise are more inconclusive, as discussed in this review. In the last decade, most of the studies have focused on IL-6 as an energy sensor' possibly secreted by skeletal muscle that activates glycogenolysis in the liver and lipolysis in fat tissue in order to provide muscle with the growing energy demands during exercise.
引用
收藏
页码:242 / 250
页数:9
相关论文
共 68 条
[41]   Immune changes: 2 h of continuous vs. intermittent cycling [J].
Nieman, D. ;
Henson, D. ;
Gojanovich, G. ;
Davis, J. M. ;
Dumke, C. ;
Utter, A. ;
Murphy, A. ;
Pearce, S. ;
McAnulty, S. ;
McAnulty, L. .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2007, 28 (07) :625-630
[42]   Muscle cytokine mRNA changes after 2.5 h of cycling: Influence of carbohydrate [J].
Nieman, DC ;
Davis, JM ;
Henson, DA ;
Gross, SJ ;
Dumke, CL ;
Utter, AC ;
Vinci, DM ;
Carson, JA ;
Brown, A ;
McAnulty, SR ;
McAnulty, LS ;
Triplett, NT .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2005, 37 (08) :1283-1290
[43]   Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run [J].
Nieman, DC ;
Davis, JM ;
Henson, DA ;
Walberg-Rankin, J ;
Shute, M ;
Dumke, CL ;
Utter, AC ;
Vinci, DM ;
Carson, JA ;
Brown, A ;
Lee, WJ ;
McAnulty, SR ;
McAnulty, LS .
JOURNAL OF APPLIED PHYSIOLOGY, 2003, 94 (05) :1917-1925
[44]   Cytokine changes after a marathon race [J].
Nieman, DC ;
Henson, DA ;
Smith, LL ;
Utter, AC ;
Vinci, DM ;
Davis, JM ;
Kaminsky, DE ;
Shute, M .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (01) :109-114
[45]   Anti-interleukin 6 receptor antibody treatment in rheumatic disease [J].
Nishimoto, N ;
Kishimoto, T ;
Yoshizaki, K .
ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 :21-27
[46]   IMMUNOLOGICAL MEDIATORS AS PARAMETERS OF THE REACTION TO STRENUOUS EXERCISE [J].
NORTHOFF, H ;
BERG, A .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 1991, 12 :S9-S15
[47]   Physical activity and plasma interleukin-6 in humans - effect of intensity of exercise [J].
Ostrowski, K ;
Schjerling, P ;
Pedersen, BK .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2000, 83 (06) :512-515
[48]   A trauma-like elevation of plasma cytokines in humans in response to treadmill running [J].
Ostrowski, K ;
Hermann, C ;
Bangash, A ;
Schjerling, P ;
Nielsen, JN ;
Pedersen, BK .
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 513 (03) :889-894
[49]   Plasma cytokine changes in relation to exercise intensity and muscle damage [J].
Peake, JM ;
Suzuki, K ;
Hordern, M ;
Wilson, G ;
Nosaka, K ;
Coombes, JS .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2005, 95 (5-6) :514-521
[50]   The Relationship Between Maximal Exercise-Induced Increases in Serum IL-6, MPO and MMP-9 Concentrations [J].
Reihmane, D. ;
Jurka, A. ;
Tretjakovs, P. .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2012, 76 (02) :188-192