Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects

被引：5

作者：

Nagasaki, Yuki ^{[1
]}

Kawai, Erika ^{[1
]}

Maruoka, Saya ^{[1
]}

Osumi, Miho ^{[1
]}

Tsukayama, Izumi ^{[1
]}

Kawakami, Yuki ^{[1
]}

Takahashi, Yoshitaka ^{[1
]}

Okazaki, Yuka ^{[2
]}

Miki, Yoshimi ^{[3
]}

Taketomi, Yoshitaka ^{[3
]}

Yamamoto, Kei ^{[4
]}

Murakami, Makoto ^{[3
]}

-Yamamoto, Toshiko Suzuki ^{[1
,5
]}

机构：

[1] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, 111 Kuboki, Okayama 7191197, Japan

[2] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nursing Sci, 111 Kuboki, Okayama 7191197, Japan

[3] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Lab Microenvironm & Metab Hlth Sci, 7 3 1 Hongo Bunkyo ku, Tokyo 1138655, Japan

[4] Tokushima Univ, Grad Sch Technol, Ind & Social Sci, 2 1 Minami jyosanjima cho, Tokushima 7708513, Japan

[5] Okayama Prefectural Univ, Dept Nutr Sci, 111 Kuboki, Okayama 7191197, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 630卷

基金：

日本学术振兴会;

关键词：

Human milk; Lipidomics; Pro -inflammatory lipid mediators; Pro -resolving lipid mediators; Mastitis; DOCOSAHEXAENOIC ACID; HEART-DISEASE; SUPPLEMENTATION; RESOLUTION; FAT; METABOLISM; NUTRITION; CELLS;

D O I：

10.1016/j.bbrc.2022.09.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Milk lipids are an important energy source for infants, but the composition of milk lipids has not yet been clarified in detail. In this study, we analyzed free fatty acids and their metabolites in milk from humans and cows. In comparison to cow milk, human milk showed a higher content of free fatty acids including polyunsaturated fatty acids, especially 6)-3 fatty acids and their metabolites. Polyunsaturated fatty acids were enriched at an early period of lactation, while saturated fatty acids did not change significantly over the period. Moreover, human milk contained high levels of 6)-3 fatty acid metabolites, particularly 18hydroxyeicosapentaenoic acid, an eicosapentaenoic acid-derived metabolite with anti-inflammatory activity. In comparison with human normal milk, thromboxane B2 and protectin D1 levels were significantly elevated in milk from individuals with mastitis, suggesting that these lipid mediators could be potential biomarkers of obstructive mastitis. Overall, the unique lipid profile of human milk supports the efficacy of breast-feeding for supply of more nutritional and bioactive lipids in comparison to artificial or cow milk to infants, in whom digestive and absorptive functions are still immature.(c) 2022 Elsevier Inc. All rights reserved.

引用

页码：84 / 91

页数：8

共 30 条

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