Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein-protein interactions

被引：25

作者：

Ardejani, Maziar S. ^{[1
,2
]}

Chok, Xiao Ling ^{[2
]}

Foo, Ce Jin ^{[2
]}

Orner, Brendan P. ^{[1
]}

机构：

[1] Kings Coll London, Sch Biomed Sci, Dept Chem, London SE1 1UL, England

[2] Nanyang Technol Univ, SPMS, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 34期

关键词：

COMPUTATIONAL DESIGN; CAGE; ENERGETICS; STABILITY; RESIDUES;

D O I：

10.1039/c3cc40886h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Computational redesign of a dimorphic protein nano-cage at the C3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 degrees C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications in protein engineering and hybrid nano-materials.

引用

页码：3528 / 3530

页数：3

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