Small RNAs in transcriptional gene silencing and genome defence

被引：580

作者：

Moazed, Danesh ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE | 2009年 / 457卷 / 7228期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRANDED-RNA; FISSION YEAST; HISTONE H3; C-ELEGANS; DNA METHYLATION; SIRNA PATHWAY; CAENORHABDITIS-ELEGANS; LYSINE-9; METHYLATION; ARABIDOPSIS-THALIANA; CHROMATIN-STRUCTURE;

D O I：

10.1038/nature07756

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small RNA molecules of about 20 - 30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin- bound non- coding RNAs and recruit chromatin modifying complexes. Interactions between small RNAs and nascent non- coding transcripts thus reveal a new mechanism for targeting chromatin- modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.

引用

收藏

页码：413 / 420

页数：8

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[1] A novel class of small RNAs bind to MILI protein in mouse testes [J].

Aravin, Alexei ;

Gaidatzis, Dimos ;

Pfeffer, Sebastien ;

Lagos-Quintana, Mariana ;

Landgraf, Pablo ;

Iovino, Nicola ;

Morris, Patricia ;

Brownstein, Michael J. ;

Kuramochi-Miyagawa, Satomi ;

Nakano, Toru ;

Chien, Minchen ;

Russo, James J. ;

Ju, Jingyue ;

Sheridan, Robert ;

Sander, Chris ;

Zavolan, Mihaela ;

Tuschl, Thomas .

NATURE, 2006, 442 (7099) :203-207

[2] The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race [J].

Aravin, Alexei A. ;

Hannon, Gregory J. ;

Brennecke, Julius .

SCIENCE, 2007, 318 (5851) :761-764

[3] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[4] MicroRNA binding sites in Arabidopsis class IIIHD-ZIP mRNAs are required for methylation of the template chromosome [J].

Bao, N ;

Lye, KW ;

Barton, MK .

DEVELOPMENTAL CELL, 2004, 7 (05) :653-662

[5] PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C-elegans [J].

Batista, Pedro J. ;

Ruby, J. Graham ;

Claycomb, Julie M. ;

Chiang, Rosaria ;

Fahlgren, Noah ;

Kasschau, Kristin D. ;

Chaves, Daniel A. ;

Gu, Weifeng ;

Vasale, Jessica J. ;

Duan, Shenghua ;

Conte, Darryl, Jr. ;

Luo, Shujun ;

Schroth, Gary P. ;

Carrington, James C. ;

Bartel, David P. ;

Mello, Craig C. .

MOLECULAR CELL, 2008, 31 (01) :67-78

[6] RNA silencing in plants [J].

Baulcombe, D .

NATURE, 2004, 431 (7006) :356-363

[7] Splicing factors facilitate RNAi-directed silencing in fission yeast [J].

Bayne, Elizabeth H. ;

Portoso, Manuela ;

Kagansky, Alexander ;

Kos-Braun, Isabelle C. ;

Urano, Takeshi ;

Ekwall, Karl ;

Alves, Flavia ;

Rappsilber, Juri ;

Allshire, Robin C. .

SCIENCE, 2008, 322 (5901) :602-606

[8] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[9] Drosophila PIWI associates with chromatin and interacts directly with HP1a [J].

Brower-Toland, Brent ;

Findley, Seth D. ;

Jiang, Ling ;

Liu, Li ;

Yin, Hang ;

Dus, Monica ;

Zhou, Pei ;

Elgin, Sarah C. R. ;

Lin, Haifan .

GENES & DEVELOPMENT, 2007, 21 (18) :2300-2311

[10] TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway [J].

Buehler, Marc ;

Spies, Noah ;

Bartel, David P. ;

Moazed, Danesh .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (10) :1015-1023

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