Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging

被引：43

作者：

Zhu, Shilei ^{[1
]}

Zhang, Jingtuo ^{[1
]}

Janjanam, Jagadeesh ^{[1
]}

Bi, Jianheng ^{[1
]}

Vegesna, Giri ^{[1
]}

Tiwari, Ashutosh ^{[1
]}

Luo, Fen-Tair ^{[2
]}

Wei, Jianjun ^{[3
]}

Liu, Haiying ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[2] Acad Sinica, Inst Chem, Taipei 11529, Taiwan

[3] CFD Res Corp, Biomed Technol Branch, Huntsville, AL 35805 USA

来源：

ANALYTICA CHIMICA ACTA | 2013年 / 758卷

基金：

美国国家科学基金会;

关键词：

BODIPY dye; Conjugated polymer; Cancer imaging; Fluorescence; RGD peptide; FLUORENE-BASED GLYCOPOLYMERS; FLUORESCENT; REGION; RED;

D O I：

10.1016/j.aca.2012.10.026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine-glycine-aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to alpha nu beta(3) integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：138 / 144

页数：7

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