Endoplasmic reticulum associated protein degradation;
Heterologous protein production;
Molecular chaperone;
Protein folding;
Unfolded protein response;
D O I:
10.1007/s10616-008-9157-9
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Production of recombinant proteins in mammalian cells is a successful technology that delivers protein pharmaceuticals for therapies and for diagnosis of human disorders. Cost effective production of protein biopharmaceuticals requires extensive optimization through cell and fermentation process engineering at the upstream and chemical engineering of purification processes at the downstream side of the production process. The majority of protein pharmaceuticals are secreted proteins. Accumulating evidence suggests that the folding and processing of these proteins in the endoplasmic reticulum (ER) is a general rate- and yield limiting step for their production. We will summarize our knowledge of protein folding in the ER and of signal transduction pathways activated by accumulation of unfolded proteins in the ER, collectively called the unfolded protein response (UPR). On the basis of this knowledge we will evaluate engineering approaches to increase cell specific productivities through engineering of the ER-resident protein folding machinery and of the UPR.
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Nishitoh, H
;
Matsuzawa, A
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Matsuzawa, A
;
Tobiume, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Tobiume, K
;
Saegusa, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Saegusa, K
;
Takeda, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Takeda, K
;
Inoue, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Inoue, K
;
Hori, S
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Hori, S
;
Kakizuka, A
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Kakizuka, A
;
Ichijo, H
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, JapanTokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Ohya, Tomoshi
;
Hayashi, Tetsuji
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Hayashi, Tetsuji
;
Kiyama, Eriko
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Kiyama, Eriko
;
Nishii, Hiroko
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Nishii, Hiroko
;
Miki, Hideo
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Miki, Hideo
;
Kobayashi, Kaoru
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Kobayashi, Kaoru
;
Honda, Kohsuke
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Honda, Kohsuke
;
Omasa, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Omasa, Takeshi
;
Ohtake, Hisao
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Nishitoh, H
;
Matsuzawa, A
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Matsuzawa, A
;
Tobiume, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Tobiume, K
;
Saegusa, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Saegusa, K
;
Takeda, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Takeda, K
;
Inoue, K
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Inoue, K
;
Hori, S
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Hori, S
;
Kakizuka, A
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
Kakizuka, A
;
Ichijo, H
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, JapanTokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Ohya, Tomoshi
;
Hayashi, Tetsuji
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Hayashi, Tetsuji
;
Kiyama, Eriko
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Kiyama, Eriko
;
Nishii, Hiroko
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Nishii, Hiroko
;
Miki, Hideo
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Miki, Hideo
;
Kobayashi, Kaoru
论文数: 0引用数: 0
h-index: 0
机构:
Mitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Kobayashi, Kaoru
;
Honda, Kohsuke
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Honda, Kohsuke
;
Omasa, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan
Omasa, Takeshi
;
Ohtake, Hisao
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Biotechnol, Grad Sch Engn, Osaka 5650871, JapanMitsubishi Tanabe Pharma Corp, Adv Med Protein Res Lab, Osaka 5731153, Japan