Adolescents carrying a missense mutation in the cart gene exhibit increased anxiety and depression

被引：48
作者：
del Giudice, EM
Santoro, N
Fiumani, P
Dominguez, G
Kuhar, MJ
Perrone, L
机构：
[1] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
[2] Univ Naples 2, Dept Pediat, Naples, Italy
来源：
DEPRESSION AND ANXIETY | 2006年 / 23卷 / 02期
关键词：
CART; mutation; depression; anxiety;
D O I：
10.1002/da.20156
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
A Leu34PHe mutation in the cocaine- and amphetamine-regulated transcript (CART) gene has been associated with severe early-onset obesity in an affected family. It has been shown that, in a cell culture system, the mutation resulted in altered CART peptide levels, and animal studies suggest that CART is involved in anxiety as well. The availability of the affected family allowed for testing of anxiety and other traits in humans carrying a mutation in CART gene. This study shows that a small group of adolescents with the mutation exhibit higher anxiety and depression scores than control subjects.
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收藏
页码：90 / 92
页数：3
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