Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

被引：26

作者：

Wu, Bin ^{[1
,2
]}

Wiese, Jutta ^{[1
]}

Schmaljohann, Rolf ^{[1
]}

Imhoff, Johannes F. ^{[1
]}

机构：

[1] GEOMAR Helmholtz Ctr Ocean Res Kiel, Marine Microbiol RD3, Dusternbrooker Weg 20, D-24105 Kiel, Germany

[2] Zhejiang Univ, Ocean Coll, Hangzhou 310058, Zhejiang, Peoples R China

来源：

MARINE DRUGS | 2016年 / 14卷 / 11期

基金：

美国国家科学基金会;

关键词：

marine fungi; glycogen synthase kinase; acetylcholinesterase; Biscogniauxia mediterranea; deep sea; RIBOSOMAL DNA; MARINE FUNGUS; IDENTIFICATION; SANSALVAMIDE; INHIBITOR; TARGET;

D O I：

10.3390/md14110204

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.

引用

页数：9

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