Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

被引:30
作者
Wu, Bin [1 ,2 ]
Wiese, Jutta [1 ]
Schmaljohann, Rolf [1 ]
Imhoff, Johannes F. [1 ]
机构
[1] GEOMAR Helmholtz Ctr Ocean Res Kiel, Marine Microbiol RD3, Dusternbrooker Weg 20, D-24105 Kiel, Germany
[2] Zhejiang Univ, Ocean Coll, Hangzhou 310058, Zhejiang, Peoples R China
基金
美国国家科学基金会;
关键词
marine fungi; glycogen synthase kinase; acetylcholinesterase; Biscogniauxia mediterranea; deep sea; RIBOSOMAL DNA; MARINE FUNGUS; IDENTIFICATION; SANSALVAMIDE; INHIBITOR; TARGET;
D O I
10.3390/md14110204
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.
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页数:9
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