Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

被引：47

作者：

Ahn, Mee Young ^{[2
]}

Kang, Dong O. ^{[3
]}

Na, Yong Jin ^{[4
]}

Yoon, Sungpil ^{[5
]}

Choi, Whan Soo ^{[6
]}

Kang, Keun Wook ^{[7
]}

Chung, Hae Young

Jung, Jee H. ^{[2
]}

Min, Do Sik ^{[3
]}

Kim, Hyung Sik ^{[1
]}

机构：

[1] Pusan Natl Univ, Mol Toxicol Lab, Coll Pharm, Pusan 609735, South Korea

[2] Wonkwang Univ, Dept Oral & Maxillofacial Pathol, Coll Dent, Wonkwang Bone Regenerat Inst,Daejeon Dent Hosp, Taejon 302120, South Korea

[3] Pusan Natl Univ, Dept Mol Biol, Coll Nat Sci, Pusan 609735, South Korea

[4] Pusan Natl Univ, Dept Obstet & Gynecol, Coll Med, Pusan 609735, South Korea

[5] Natl Canc Ctr, Res Inst, Goyang Si, Gyeonggi Do, South Korea

[6] Konkuk Univ, Inst Biomed Sci & Technol, Coll Med, Chungju 380701, South Korea

[7] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

来源：

CANCER LETTERS | 2012年 / 325卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

HDAC inhibitor; Ovarian cancer; Migration; Apicidin; HDAC4; HUMAN ENDOMETRIAL; IN-VIVO; MATRIX METALLOPROTEINASES; ANTICANCER AGENTS; GENE-EXPRESSION; SP1; SITES; INVASION; METASTASIS; RECK; P21(WAF1/CIP1);

D O I：

10.1016/j.canlet.2012.06.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of RECK in the HDAC4-blocked SKOV-3 cells. Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：189 / 199

页数：11

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