Thrombosis and coagulopathy in COVID-19: An illustrated review

被引：43

作者：

Levi, Marcel ^{[1
,2
]}

Hunt, Beverley J. ^{[3
]}

机构：

[1] Univ Coll London Hosp NHS Fdn Trust, Dept Med, London, England

[2] Univ Coll London Hosp NHS Fdn Trust, Cardiometab Programme NIHR UCLH UCL BRC, London, England

[3] Guys & St Thomas NHS Fdn Trust, Thrombosis & Haemophilia Ctr, London, England

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2020年 / 4卷 / 05期

关键词：

COVID-19; novel coronavirus; thrombosis; coagulopathy; coagulation; CORONAVIRUS DISEASE 2019;

D O I：

10.1002/rth2.12400

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID-19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute-phase proteins, very high levels of D-dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID-19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).

引用

页码：744 / 751

页数：8

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