The role of progranulin in arthritis

被引：55
作者：
Wei, Jianlu [1 ,2 ]
Hettinghouse, Aubryanna [1 ]
Liu, Chuanju [1 ,3 ]
机构：
[1] NYU, Med Ctr, Dept Orthopaed Surg, New York, NY USA
[2] Shandong Univ, Dept Orthopaed Surg, Sch Med, Jinan, Shandong, Peoples R China
[3] NYU, Sch Med, Dept Cell Biol, Room 1608,HJD,301 East 17th St, New York, NY 10003 USA
来源：
MUSCULOSKELETAL REPAIR AND REGENERATION | 2016年 / 1383卷
关键词：
progranulin; TNFR; arthritis; bone regeneration; OLIGOMERIC MATRIX PROTEIN; GRANULIN-EPITHELIN PRECURSOR; GROWTH-FACTOR PROGRANULIN; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; SYNTHASE TYPE-II; ARTICULAR-CARTILAGE; TNF-ALPHA; RHEUMATOID-ARTHRITIS; IN-VIVO;
D O I：
10.1111/nyas.13191
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Progranulin (PGRN) is a growth factor with a unique beads-on-a-string structure that is involved in multiple pathophysiological processes, including anti-inflammation, tissue repair, wound healing, neurodegenerative diseases, and tumorigenesis. This review presents up-to-date information concerning recent studies on the role of PGRN in inflammatory arthritis and osteoarthritis, with a special focus on the involvement of the interactions and interplay between PGRN and tumor necrosis factor receptor (TNFR) family members in regulating such musculoskeletal diseases. In addition, this paper highlights the applications of atsttrin, an engineered protein comprising three TNFR-binding fragments of PGRN, as a promising intervention in treating arthritis.
引用
收藏
页码：5 / 20
页数：16
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