Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft

被引：40

作者：

Fishbein, Gregory A. ^{[1
]}

Fishbein, Michael C. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

HUMAN IMMUNOLOGY | 2012年 / 73卷 / 12期

关键词：

CORONARY-ARTERY-DISEASE; HUMORAL REJECTION; HEART-TRANSPLANTATION; VASCULAR REJECTION; CELLULAR REJECTION; C4D; COMPLEMENT; DIAGNOSIS; BIOPSIES; IMMUNOFLUORESCENCE;

D O I：

10.1016/j.humimm.2012.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recognition and acceptance of the entity of antibody-mediated rejection (AMR) of solid organs has been slow to develop. Greatest acceptance and most information relates to cardiac transplantation. AMR is thought to represent antibody/complement mediated injury to the microvasculature of the graft that can result in allograft dysfunction, allograft loss, accelerated graft vasculopathy, and increased mortality. The morphologic hallmark is microvascular injury with immunoglobulin and complement deposition in capillaries, accumulation of intravascular macrophages, and in more severe cases, microvascular hemorrhage and thrombosis, with inflammation and edema of the affected organ. Understanding of the pathogenesis of AMR, criteria and methods for diagnosis, and treatment strategies are still in evolution, and will be addressed in this review. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：1213 / 1217

页数：5

共 24 条

[1] Incidence of humoral rejection in heart transplant recipients treated with tacrolimus or cyclosporine A [J].

Behr, TM ;

Richter, K ;

Fischer, P ;

Spes, CH ;

Meiser, B ;

Reichart, B ;

Pongratz, D ;

Feucht, H ;

Theisen, K ;

Angermann, CE .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (05) :1920-1921

[2] The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: Evolution and current status (2005-2011) [J].

Berry, Gerald J. ;

Angelini, Annalisa ;

Burke, Margaret M. ;

Bruneval, Patrick ;

Fishbein, Michael C. ;

Hammond, Elizabeth ;

Miller, Dylan ;

Neil, Desley ;

Revelo, Monica P. ;

Rodriguez, E. Rene ;

Stewart, Susan ;

Tan, Carmela D. ;

Winters, Gayle L. ;

Kobashigawa, Jon ;

Mehra, Mandeep R. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (06) :601-611

[3]

BONNAUD EN, 1995, J HEART LUNG TRANSPL, V14, P163

[4] Humoral rejection in pediatric orthotopic heart transplantation [J].

Casarez, Tim W. ;

Perens, Gregory ;

Williams, Ryan J. ;

Kutay, Erin ;

Fishbein, Michael C. ;

Reed, Elaine F. ;

Alejos, Juan C. ;

Levi, Daniel S. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2007, 26 (02) :114-119

[5]

Chantranuwat C, 2004, APPL IMMUNOHISTO M M, V12, P166

[6] Humoral heart rejection (Severe allograft dysfunction with no signs of cellular rejection or ischemia):: Incidence, management, and the value of C4d for diagnosis [J].

Crespo-Leiro, MG ;

Veiga-Barreiro, A ;

Doménech, N ;

Paniagua, MJ ;

Piñón, P ;

González-Cuesta, M ;

Vázquez-Martul, E ;

Ramirez, C ;

Cuenca, JJ ;

Castro-Beiras, A .

AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (10) :2560-2564

[7] Biopsy-negative cardiac transplant rejection: etiology, diagnosis, and therapy [J].

Fishbein, MC ;

Kobashigawa, J .

CURRENT OPINION IN CARDIOLOGY, 2004, 19 (02) :166-169

[8]

HAMMOND EH, 1989, J HEART TRANSPLANT, V8, P430

[9]

HAMMOND EH, 1991, TRANSPLANT P, V23, P26

[10] RELATIONSHIP OF OKT3 SENSITIZATION AND VASCULAR REJECTION IN CARDIAC TRANSPLANT PATIENTS RECEIVING OKT3 REJECTION PROPHYLAXIS [J].

HAMMOND, EH ;

WITTWER, CT ;

GREENWOOD, J ;

KNAPE, WA ;

YOWELL, RL ;

MENLOVE, RL ;

CRAVEN, C ;

RENLUND, DG ;

BRISTOW, MR ;

DEWITT, CW ;

OCONNELL, JB .

TRANSPLANTATION, 1990, 50 (05) :776-782

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