Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers

被引：18
|
作者：
Pravica, Vera [1 ]
Popadic, Dusan [1 ]
Savic, Emina [1 ]
Markovic, Milos [1 ]
Drulovic, Jelena [2 ]
Mostarica-Stojkovic, Marija [1 ]
机构：
[1] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade 11000, Serbia
[2] Univ Belgrade, Sch Med, Inst Neurol CCS, Belgrade, Serbia
来源：
IMMUNOLOGIC RESEARCH | 2012年 / 52卷 / 1-2期
关键词：
Multiple sclerosis; Genetic polymorphism; Biomarkers; Interferon beta; Pharmacogenomics; Ethnic variations; INTERFERON-BETA THERAPY; GENOME-WIDE ASSOCIATION; MESSENGER-RNA EXPRESSION; ALPHA PROMOTER POLYMORPHISMS; TNF-ALPHA; T-CELLS; CONFER SUSCEPTIBILITY; GENE POLYMORPHISM; NEUTRALIZING ANTIBODIES; INTERLEUKIN-7; RECEPTOR;
D O I：
10.1007/s12026-012-8273-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by unpredictable and variable clinical course. Etiology of MS involves both genetic and environmental factors. New technologies identified genetic polymorphisms associated with MS susceptibility among which immunologically relevant genes are significantly overrepresented. Although individual genes contribute only a small part to MS susceptibility, they might be used as biomarkers, thus helping to identify accurate diagnosis, predict clinical disease course and response to therapy. This review focuses on recent progress in research on MS genetics with special emphasis on the possibility to use single nucleotide polymorphism of candidate genes as biomarkers of susceptibility to disease and response to therapy.
引用
收藏
页码：42 / 52
页数：11
相关论文
共 50 条
  • [41] The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort
    Qiu, Wei
    Kym Pham
    James, Ian
    Nolan, David
    Castley, Allison
    Christiansen, Frank T.
    Czarniak, Petra
    Luo, Yuebei
    Wu, Jingshan
    Garlepp, Michael
    Wilton, Steve
    Carroll, William M.
    Mastaglia, Frank L.
    Kermode, Allan G.
    JOURNAL OF NEUROIMMUNOLOGY, 2013, 261 (1-2) : 92 - 97
  • [42] The evaluation of VEGF and HIF-1α gene polymorphisms and multiple sclerosis susceptibility
    Saravani, Mohsen
    Rokni, Mohsen
    Mehrbani, Mehrzad
    Amirkhosravi, Arian
    Faramarz, Sanaz
    Fatemi, Iman
    Tarzi, Mojdeh Esmaeili
    Nematollahi, Mohammad Hadi
    JOURNAL OF GENE MEDICINE, 2019, 21 (12)
  • [43] Exploration of deleterious single nucleotide polymorphisms in late-onset Alzheimer disease susceptibility genes
    Masoodi, Tariq Ahmad
    Al Shammari, Sulaiman A.
    Al-Muammar, May N.
    Alhamdan, Adel A.
    Talluri, Venkateswar Rao
    GENE, 2013, 512 (02) : 429 - 437
  • [44] Association of nod-like receptor protein-3 single nucleotide gene polymorphisms and expression with the susceptibility to relapsing-remitting multiple sclerosis
    Imani, Danyal
    Azimi, Amirreza
    Salehi, Zahra
    Rezaei, Nima
    Emamnejad, Rahimeh
    Sadr, Maryam
    Izad, Maryam
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2018, 45 (06) : 329 - 336
  • [45] IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response
    Leyva, L
    Fernández, O
    Fedetz, M
    Blanco, E
    Fernández, VE
    Oliver, B
    León, A
    Pinto-Medel, MJ
    Mayorga, C
    Guerrero, M
    Luque, G
    Alcina, A
    Matesanz, F
    JOURNAL OF NEUROIMMUNOLOGY, 2005, 163 (1-2) : 165 - 171
  • [46] Prediction of single-nucleotide polymorphisms within microRNAs binding sites of neuronal genes related to multiple sclerosis: A preliminary study
    Dehghanzad, Reyhaneh
    Panahi Moghadam, Somayeh
    Shirvani Farsani, Zeinab
    ADVANCED BIOMEDICAL RESEARCH, 2021, 10 (01): : 8
  • [47] Factors influencing daily treatment choices in multiple sclerosis: practice guidelines, biomarkers and burden of disease
    Berger, Thomas
    Adamczyk-Sowa, Monika
    Csepany, Tunde
    Fazekas, Franz
    Fabjan, Tanja Hojs
    Horakova, Dana
    Ledinek, Alenka Horvat
    Illes, Zsolt
    Kobelt, Gisela
    Jazbec, Sasa Sega
    Klimova, Eleonora
    Leutmezer, Fritz
    Rejdak, Konrad
    Rozsa, Csilla
    Sellner, Johann
    Selmaj, Krzysztof
    Stourac, Pavel
    Szilasiova, Jarmila
    Turcani, Peter
    Vachova, Marta
    Vaneckova, Manuela
    Vecsei, Laszlo
    Havrdova, Eva Kubala
    THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2020, 13
  • [48] Two Single Nucleotide Polymorphisms in the Purinergic Receptor P2X7 Gene Are Associated with Disease Severity in Multiple Sclerosis
    Guerini, Franca Rosa
    Agliardi, Cristina
    Bolognesi, Elisabetta
    Zanzottera, Milena
    Caputo, Domenico
    Pasanisi, Maria Barbara
    Rovaris, Marco
    Clerici, Mario
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [49] Single nucleotide polymorphisms of lncRNA H19 are not associated with risk of multiple sclerosis in Iranian population
    Mazdeh, Mehrdokht
    Noroozi, Rezvan
    Komaki, Alireza
    Taheri, Mohammad
    Ghafouri-Fard, Soudeh
    META GENE, 2019, 21
  • [50] IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis
    O H Kantarci
    A Goris
    D D Hebrink
    S Heggarty
    S Cunningham
    I Alloza
    E J Atkinson
    M de Andrade
    C T McMurray
    C A Graham
    S A Hawkins
    A Billiau
    B Dubois
    B G Weinshenker
    K Vandenbroeck
    Genes & Immunity, 2005, 6 : 153 - 161
12345