Graphene oxide-based drug delivery vehicles: functionalization, characterization, and cytotoxicity evaluation

被引：74
|
作者：
Makharza, Sami [1 ]
Cirillo, Giuseppe [1 ,2 ]
Bachmatiuk, Alicja [3 ,4 ,5 ]
Ibrahim, Imad [1 ]
Ioannides, Nicholas [6 ]
Trzebicka, Barbara [5 ]
Hampel, Silke [1 ]
Ruemmeli, Mark H. [3 ,4 ]
机构：
[1] IFW Dresden, D-01171 Dresden, Germany
[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy
[3] Inst for Basic Sci Korea, IBS Ctr Integrated Nanostruct Phys, Taejon 305701, South Korea
[4] Sungkyunkwan Univ, Dept Phys, Dept Energy, Suwon 440746, South Korea
[5] Polish Acad Sci, Ctr Polymer & Carbon Mat, PL-41819 Zabrze, Poland
[6] London Metropolitan Univ, Fac Life Sci & Comp, London N7 8DB, England
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2013年 / 15卷 / 12期
关键词：
Graphene oxide; Nanocarrier; Drug therapy; Health effects; Nanomedicine; WALL CARBON NANOTUBES; WATER-SOLUBLE FULLERENE; GRAPHITE OXIDE; MECHANICAL-PROPERTIES; PHOTOTHERMAL THERAPY; RAMAN-SPECTROSCOPY; CONTROLLED-RELEASE; OXIDATIVE STRESS; CHEMICAL-REDUCTION; PULMONARY TOXICITY;
D O I：
10.1007/s11051-013-2099-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As a consequence of graphene oxides (GOs) high chemical versatility, there is great interest in functionalized as a nanocarrier for in vitro and in vivo drug delivery. Within this review, the structure and properties of GO that allow covalent and non-covalent functionalization are discussed. In short, toxicity investigations show functionalized GO is biocompatible. Various works demonstrate the potential of GO derivatives as exciting nanocarriers for the loading and delivery of therapeutic drugs.
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页数：26
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