The role of statins in cancer prevention and treatment

被引：0
作者：
Stamm, Jason A.
Ornstein, Deborah L.
机构：
[1] Univ Vermont, Coll Med, Hematol Oncol Unit, Fletcher Allen Hlth Care,Vermont Canc Ctr, Burlington, VT 05401 USA
[2] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA
来源：
ONCOLOGY-NEW YORK | 2005年 / 19卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Statins inhibit the activity of the rate-limiting enzyme in the cholesterol biosynthetic pathway, HMG-CoA reductase, and are widely prescribed for lowering plasma lipid levels. Several statins have antitumor effects in experimental models, and observational studies suggest that this anticancer activity in the laboratory may translate into effective treatments and/or preventive strategies for certain human cancers. This paper reviews the laboratory and clinical evidence that statins have anticancer activity, discusses the possible mechanisms by which tumor growth may be inhibited by this class of drugs, and outlines strategies for the evaluation of these agents in the prevention and treatment of human cancers.
引用
收藏
页码：739 / 750
页数：12
相关论文
共 104 条
  • [1] Proteasome inhibitors as new anticancer drugs
    Adams, J
    [J]. CURRENT OPINION IN ONCOLOGY, 2002, 14 (06) : 628 - 634
  • [2] Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells
    Agarwal, B
    Halmos, B
    Feoktistov, AS
    Protiva, P
    Ramey, WG
    Chen, M
    Pothoulakis, C
    Lamont, JT
    Holt, PR
    [J]. CARCINOGENESIS, 2002, 23 (03) : 521 - 528
  • [3] Agarwal B, 1999, CLIN CANCER RES, V5, P2223
  • [4] [Anonymous], 2002, JAMA
  • [5] HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes
    Assmus, B
    Urbich, C
    Aicher, A
    Hofmann, WK
    Haendeler, J
    Rössig, L
    Spyridopoulos, I
    Zeiher, AM
    Dimmeler, S
    [J]. CIRCULATION RESEARCH, 2003, 92 (09) : 1049 - 1055
  • [6] Austen B, 2002, J Nutr Health Aging, V6, P377
  • [7] Risk for myopathy with statin therapy in high-risk patients
    Ballantyne, CM
    Corsini, A
    Davidson, MH
    Holdaas, H
    Jacobson, TA
    Leitersdorf, E
    März, W
    Reckless, JPD
    Stein, EA
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (05) : 553 - 564
  • [8] HMG CoA reductase inhibitors and the skeleton: a comprehensive review
    Bauer, DC
    [J]. OSTEOPOROSIS INTERNATIONAL, 2003, 14 (04) : 273 - 282
  • [9] Statin use and the risk of breast cancer
    Beck, P
    Wysowski, DK
    Downey, W
    Butler-Jones, D
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (03) : 280 - 285
  • [10] Do statins cause cancer? A meta-analysis of large randomized clinical trials
    Bjerre, LM
    LeLorier, J
    [J]. AMERICAN JOURNAL OF MEDICINE, 2001, 110 (09) : 716 - 723
12345678910