Convergent Antibody Signatures in Human Dengue

被引：195

作者：

Parameswaran, Poornima ^{[1
,2
]}

Liu, Yi ^{[3
,5
]}

Roskin, Krishna M. ^{[2
]}

Jackson, Katherine K. L. ^{[2
]}

Dixit, Vaishali P. ^{[2
]}

Lee, Ji-Yeun ^{[2
]}

Artiles, Karen L. ^{[2
]}

Zompi, Simona ^{[1
]}

Jose Vargas, Maria ^{[6
]}

Simen, Birgitte B. ^{[7
]}

Hanczaruk, Bozena ^{[7
]}

McGowan, Kim R. ^{[7
]}

Tariq, Muhammad A. ^{[8
]}

Pourmand, Nader ^{[8
]}

Koller, Daphne ^{[3
]}

Balmaseda, Angel ^{[6
]}

Boyd, Scott D. ^{[2
]}

Harris, Eva ^{[1
]}

Fire, Andrew Z. ^{[2
,4
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[2] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Biomed Informat Training Program, Stanford, CA 94305 USA

[6] Ctr Nacl Diagnos & Referencia, Lab Nacl Virol, Minist Hlth, Managua 16064, Nicaragua

[7] Roche Co, 454 Life Sci, Branford, CT 06405 USA

[8] Univ Calif Santa Cruz, Baskin Sch Engn, Santa Cruz, CA 95064 USA

来源：

CELL HOST & MICROBE | 2013年 / 13卷 / 06期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; GENE REARRANGEMENTS; MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; INFLUENZA-VIRUS; DIVERSITY; REGION; REPERTOIRE; ALIGNMENT; PATHOGENESIS;

D O I：

10.1016/j.chom.2013.05.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue is the most prevalent mosquito-borne viral disease in humans, and the lack of early prognostics, vaccines, and therapeutics contributes to immense disease burden. To identify patterns that could be used for sequence-based monitoring of the antibody response to dengue, we examined antibody heavy-chain gene rearrangements in longitudinal peripheral blood samples from 60 dengue patients. Comparing signatures between acute dengue, postrecovery, and healthy samples, we found increased expansion of B cell clones in acute dengue patients, with higher overall clonality in secondary infection. Additionally, we observed consistent antibody sequence features in acute dengue in the highly variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specific CDR3 sequences highly enriched in acute samples compared to postrecovery, healthy, or non-dengue samples. Dengue thus provides a striking example of a human viral infection where convergent immune signatures can be identified in multiple individuals. Such signatures could facilitate surveillance of immunological memory in communities.

引用

页码：691 / 700

页数：10

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