Cyclotide biosynthesis

被引：73

作者：

Craik, David J. ^{[1
]}

Malik, Uru ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2013年 / 17卷 / 04期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CYCLIC PEPTIDE TOXINS; CIRCULAR PROTEINS; PLANT CYCLOTIDES; OLDENLANDIA-AFFINIS; CYSTINE KNOT; KALATA B1; CHEMICAL-SYNTHESIS; FLOWERING PLANTS; DISCOVERY; CYCLIZATION;

D O I：

10.1016/j.cbpa.2013.05.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclotides are bioactive macrocyclic peptides from plants that are characterized by their exceptional stability and potential applications as protein engineering or drug design frameworks. Their stability arises from their unique cyclic cystine knot structure, which combines a head-to-tail cyclic peptide backbone with three conserved disulfide bonds having a knotted topology. Cyclotides are ribosomally synthesized by plants and expressed in a wide range of tissues, including leaves, flowers, stems and roots. Here we describe recent studies that have examined the biosynthesis of cyclotides and in particular the mechanism associated with post-translational backbone cyclization.

引用

页码：546 / 554

页数：9

共 67 条

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