Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma

被引:7
作者
Rava, Marta [1 ,8 ]
Le Moual, Nicole [1 ,8 ]
Dumont, Xavier [9 ]
Guerra, Stefano [10 ,11 ]
Siroux, Valerie [4 ,5 ,6 ,7 ]
Jacquemin, Benedicte [1 ,8 ,10 ]
Kauffmann, Francine [2 ,3 ]
Bernard, Alfred [9 ]
Nadif, Rachel [1 ,8 ]
机构
[1] INSERM, VIMA Aging & Chron Dis Epidemiol & Publ Hlth, Villejuif, France
[2] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, Villejuif, France
[3] Univ Paris 11, Villejuif, France
[4] Univ Grenoble Alpes, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, Grenoble, France
[5] INSERM, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, Grenoble, France
[6] Univ Hosp Grenoble, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, Grenoble, France
[7] INSERM, Inst Albert Bonniot, La Tronche, France
[8] Univ Versailles St Quentin En Yvelines, Versailles, France
[9] Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol LTAP, Brussels, Belgium
[10] CIBERESP, IMIM Hosp del Mar, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
[11] Univ Arizona, Arizona Resp Ctr, Tucson, AZ USA
关键词
airway hyper-reactivity; asthma; biological marker; lung function test; uteroglobin; SECRETORY PROTEIN; BRONCHIAL HYPERRESPONSIVENESS; A38G POLYMORPHISM; LUNG-FUNCTION; CC16; TIME; EXPOSURES; BIOMARKER; PLASMA; ATOPY;
D O I
10.1111/resp.12609
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background and objective: Club cell secretory protein (CC-16) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic lung diseases because of its presumed relationship to inflammation. Little is known about the association between CC-16 serum level and asthma, lung function and airway responsiveness (AR). Methods: SerumCC-16 level was determined by latex immunoassay in 1298 participants from the French Epidemiological case-control and family-based study on Genetics and Environment of Asthma (EGEA) (mean age 43 years; 49% men, 38% with asthma). Pre-bronchodilator lung function (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) and degree of AR, expressed as a function of the dose-response slope to methacholine test were measured. Standardized residuals CC-16 z-scores were obtained by regressing CC-16 level on the glomerular filtration rate. CC-16 z-scores were correlated with asthma, lung function and AR in participants with and without asthma. Results: CC-16 geometric mean level was 12.4 mu g/L (range: 2.2-70.6 mu g/L). In participants without asthma, lower CC-16 z-scores was associated with impaired FEV1/FVC% (beta = 0.50 (95% CI: 0.06, 0.95) and with higher degree of AR (beta = 0.24 (95% CI: 0.09, 0.39)). CC-16 was not associated with impaired lung function or AR in participants with asthma. Conclusions: Lower CC-16 serum level was associated with impaired lung function and AR, suggesting that serumCC-16 level may reflect early damages to the lung epithelium in adults without asthma.
引用
收藏
页码:1198 / 1205
页数:8
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