Synthesis and biological evaluation of novel 99mTc labeled ornidazole xanthate complexes as potential hypoxia imaging agents

被引：11
作者：
Li, Zhenxiang [1 ]
Song, Xiaoqing [1 ]
Zhang, Junbo [1 ]
机构：
[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2015年 / 306卷 / 02期
基金：
北京市自然科学基金; 中国国家自然科学基金;
关键词：
Ornidazole; Xanthate; Tc-99m; Hypoxia; Tumor imaging; IN-VIVO; DEOXYGLUCOSE DITHIOCARBAMATE; TUMOR; BIODISTRIBUTION; MARKER; VITRO; DERIVATIVES; BEARING;
D O I：
10.1007/s10967-015-4125-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, ornidazole xanthate (ONXT) ligand was successfully synthesized and its Tc-99m-nitrido core, Tc-99m-oxo core and [Tc-99m(CO)(3)](+) core complexes were prepared with high yields. The tumor cell experiments and the biodistribution in mice bearing S180 tumor showed that all of the complexes had a certain hypoxic selectivity and tumor uptake. Among them, (TcO)-Tc-99m-ONXT exhibited the highest tumor uptake and tumor/muscle ratio. Planar scintigraphic imaging studies showed the tumor detection was observable, suggesting it would be a potential radiotracer to target tumor hypoxia.
引用
收藏
页码：535 / 542
页数：8
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