Recent Advances in the Construction of Flexible Sensors for Biomedical Applications

被引:30
作者
Zhou, Nan [1 ]
Liu, Tianjiao [1 ]
Wen, Bianying [2 ]
Gong, Coucong [3 ]
Wei, Gang [3 ,4 ]
Su, Zhiqiang [1 ]
机构
[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing Key Lab Adv Funct Polymer Composites, Beijing 100029, Peoples R China
[2] Beijing Technol & Business Univ, Sch Mat & Mech Engn, Beijing Key Lab Qual Evaluat Technol Hyg & Safety, China 100048, Peoples R China
[3] Univ Bremen, Fac Prod Engn, D-28359 Bremen, Germany
[4] Qingdao Univ, Coll Chem & Chem Engn, Qingdao 266071, Peoples R China
基金
中国国家自然科学基金;
关键词
biomedical applications; carbon nanomaterials; flexible biosensors; nanoparticles; polymer; CARBON NANOTUBES; SENSITIVE DETECTION; GRAPHENE OXIDE; ELECTROCHEMICAL SENSORS; SELECTIVE DETECTION; PRESSURE SENSORS; GREEN SYNTHESIS; BIOSENSOR; NANOPARTICLES; IMMUNOSENSOR;
D O I
10.1002/biot.202000094
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The fabrication of flexible sensors is a potential way to promote the progress of modern social science and technology due to their wide applications in high-performance electronic equipment and devices. Flexible sensors based on organic materials combine the unique advantages of flexibility and low cost, increasing interest in healthcare monitoring, treatment, and human-machine interfaces. Advances in materials science and biotechnology have rapidly accelerated the development of bio-integrated multifunctional sensors and devices. Due to their excellent mechanical and electrical properties, many types of functional materials provided benefits for the construction of various sensors with improved flexibility and stretchability. In this review, recent advance in the fabrication of flexible sensors by using functional nanomaterials including nanoparticles, carbon materials, metal-organic materials, and polymers is presented. In addition, the potential biomedical applications of the fabricated flexible sensors for detecting gas molecules signals, small molecules, DNA/RNA, proteins, others are introduced and discussed.
引用
收藏
页数:13
相关论文
共 100 条
[1]   Applications of commercial biosensors in clinical, food, environmental, and biothreat/biowarfare analyses [J].
Bahadir, Elif Burcu ;
Sezginturk, Mustafa Kemal .
ANALYTICAL BIOCHEMISTRY, 2015, 478 :107-120
[2]   Highly Stretchable Fully-Printed CNT-Based Electrochemical Sensors and Biofuel Cells: Combining Intrinsic and Design-Induced Stretchability [J].
Bandodkar, Amay J. ;
Jeerapan, Itthipon ;
You, Jung-Min ;
Nunez-Flores, Rogelio ;
Wang, Joseph .
NANO LETTERS, 2016, 16 (01) :721-727
[3]   Detection of Benzene and Volatile Aromatic Compounds by Molecularly Imprinted Polymer-Coated Quartz Crystal Microbalance Sensor [J].
Banerjee, Mahuya Bhattacharyya ;
Pradhan, Susmita ;
Roy, Runu Banerjee ;
Tudu, Bipan ;
Das, Dipak Kumar ;
Bandyopadhyay, Rajib ;
Pramanik, Panchanan .
IEEE SENSORS JOURNAL, 2019, 19 (03) :885-892
[4]   Ultrasensitive cardiac troponin I antibody based nanohybrid sensor for rapid detection of human heart attack [J].
Bhatnagar, Deepika ;
Kaur, Inderpreet ;
Kumar, Ashok .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 95 :505-510
[5]   Chemiresistive nanosensors with convex/concave structures [J].
Chen, Songyue ;
Tang, Yongliang ;
Zhan, Kan ;
Sun, Daoheng ;
Hou, Xu .
NANO TODAY, 2018, 20 :84-100
[6]   In situ growth of FeOOH nanoparticles on physically-exfoliated graphene nanosheets as high performance H2O2 electrochemical sensor [J].
Chen, Xuerong ;
Gao, Juan ;
Zhao, Guoqian ;
Wu, Can .
SENSORS AND ACTUATORS B-CHEMICAL, 2020, 313
[7]   The sensitive detection of single-cell secreted lactic acid for glycolytic inhibitor screening with a microdroplet biosensor [J].
Chen, Xuyue ;
Shen, Rui ;
Liu, Sidi ;
Xiao, Xiang ;
Yan, Jun ;
Zhang, Yiqiu ;
Jiang, Zhongyun ;
Nie, Baoqing ;
Liu, Jian .
ANALYTICAL METHODS, 2020, 12 (25) :3250-3259
[8]   Amperometric DNA biosensor for Mycobacterium tuberculosis detection using flower-like carbon nanotubes-polyaniline nanohybrid and enzyme-assisted signal amplification strategy [J].
Chen, Yuhan ;
Guo, Shuliang ;
Zhao, Min ;
Zhang, Pu ;
Xin, Zhuliu ;
Tao, Jiang ;
Bai, Lijuan .
BIOSENSORS & BIOELECTRONICS, 2018, 119 :215-220
[9]   Current Technologies of Electrochemical Immunosensors: Perspective on Signal Amplification [J].
Cho, Il-Hoon ;
Lee, Jongsung ;
Kim, Jiyeon ;
Kang, Min-soo ;
Paik, Jean Kyung ;
Ku, Seockmo ;
Cho, Hyun-Mo ;
Irudayaraj, Joseph ;
Kim, Dong-Hyung .
SENSORS, 2018, 18 (01)
[10]   Chemical reduction of graphene oxide: a synthetic chemistry viewpoint [J].
Chua, Chun Kiang ;
Pumera, Martin .
CHEMICAL SOCIETY REVIEWS, 2014, 43 (01) :291-312