Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland

被引：41

作者：

Lu, XJ ^{[1
]}

Pinto, AK ^{[1
]}

Kelly, AM ^{[1
]}

Cho, KS ^{[1
]}

Hill, AB ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 08期

关键词：

D O I：

10.1128/JVI.80.8.4200-4202.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMVs known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.

引用

页码：4200 / 4202

页数：3

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