Silica imprinted materials containing pharmaceuticals as a template: textural aspects

Silica-based materials were prepared by the acid catalyzed sol-gel method using different pharmaceuticals as a template. The template molecules investigated were fluoxetine, gentamicin, lidocaine, morphine, nifedipine, paracetamol and tetracycline. The resulting hybrid silicas underwent ultrasound extraction in the presence of several solvents and were characterized by elemental analysis, porosimetry by adsorption/desorption of nitrogen (BET method), small-angle X-ray scattering and X-ray diffraction. Drug extraction was carried out by the combination of solvent and ultra-sound. The textural characteristics of the hybrid xerogels and resulting imprinted materials were shown to be highly dependent on the molecular weight and molecular volume of the drug template. Increasing the molecular weight of the template results in a decrease in the encapsulation content of the resulting material. In the case of paracetamol and fluoxetine, the dimensions of the surface area are not sufficient to guarantee the adsorption of the smaller molecule. Instead, the shape generated through encapsulation and extraction during the production of the imprinted silica dictates the adsorption behavior.