Human Milk Composition Nutrients and Bioactive Factors

被引:1877
作者
Ballard, Olivia [1 ]
Morrow, Ardythe L. [2 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Ctr Interdisciplinary Res Human Milk & Lactat, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Ctr Interdisciplinary Res Human Milk & Lactat, Perinatal Inst, Cincinnati, OH 45229 USA
关键词
Human milk composition; Breastfeeding; Infant nutrition; Pasteurization; Bioactive factors; EPIDERMAL-GROWTH-FACTOR; COLONY-STIMULATING FACTOR; HUMAN-IMMUNODEFICIENCY-VIRUS; NECROSIS-FACTOR-ALPHA; I IGF-I; MIGRATION INHIBITORY FACTOR; BREAST-FED INFANTS; FACTOR-FACTOR VIII; FACTOR-BETA; POSTNATAL TRANSMISSION;
D O I
10.1016/j.pcl.2012.10.002
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
This article provides an overview of the composition of human milk, its variation, and its clinical relevance. The composition of human milk is the biological norm for infant nutrition. Human milk also contains many hundreds to thousands of distinct bioactive molecules that protect against infection and inflammation and contribute to immune maturation, organ development, and healthy microbial colonization. Some of these molecules (eg, lactoferrin) are being investigated as novel therapeutic agents. Human milk changes in composition from colostrum to late lactation, within feeds, by gestational age, diurnally, and between mothers. Feeding infants with expressed human milk is increasing.
引用
收藏
页码:49 / +
页数:28
相关论文
共 211 条
[1]   Mother's Milk, Feeding Strategies, and Lactoferrin to Prevent Necrotizing Enterocolitis [J].
Adamkin, David H. .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2012, 36 :25S-29S
[2]   Immune Markers in Breast Milk and Fetal and Maternal Body Fluids: A Systematic Review of Perinatal Concentrations [J].
Agarwal, Saroochi ;
Karmaus, Wilfried ;
Davis, Susan ;
Gangur, Venu .
JOURNAL OF HUMAN LACTATION, 2011, 27 (02) :171-186
[3]  
Agennix, PHAS 1 2 STUD TAL OR
[4]   Alterations in the Host Defense Properties of Human Milk Following Prolonged Storage or Pasteurization [J].
Akinbi, Henry ;
Meinzen-Derr, Jareen ;
Auer, Christine ;
Ma, Yan ;
Pullum, Derek ;
Kusano, Ryosuke ;
Reszka, Krzysztof J. ;
Zimmerly, Kira .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 51 (03) :347-352
[5]   B Vitamins in Breast Milk: Relative Importance of Maternal Status and Intake, and Effects on Infant Status and Function [J].
Allen, Lindsay H. .
ADVANCES IN NUTRITION, 2012, 3 (03) :362-369
[6]  
American Academy of Pediatrics, 2009, PEDIAT NUTR HDB
[7]   Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance [J].
Ando, Takashi ;
Hatsushika, Kyosuke ;
Wako, Masanori ;
Ohba, Tetsuro ;
Koyama, Kensuke ;
Ohnuma, Yuko ;
Katoh, Ryohei ;
Ogawa, Hideoki ;
Okumura, Ko ;
Luo, Jian ;
Wyss-Coray, Tony ;
Nakao, Atsuhito .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (04) :916-923
[8]  
[Anonymous], 2003, INF YOUNG CHILD NUTR
[9]   Association between Breast Milk Erythropoietin and Reduced Risk of Mother-to-Child Transmission of HIV [J].
Arsenault, Joanne E. ;
Webb, Aimee L. ;
Koulinska, Irene N. ;
Aboud, Said ;
Fawzi, Wafaie W. ;
Villamor, Eduardo .
JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (03) :370-373
[10]  
Arslanoglu S, 2010, J PERINAT MED, V38, P233, DOI [10.1515/JPM.2010.073, 10.1515/jpm.2010.073]