Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

被引：8
|
作者：
Al-Harthy, Thuraya [1 ]
Zoghaib, Wajdi M. [1 ]
Stoll, Raphael [2 ]
Abdel-Jalil, Raid [1 ]
机构：
[1] Sultan Qaboos Univ, Dept Chem, Coll Sci, Muscat, Oman
[2] Ruhr Univ Bochum, Biomol NMR, D-44780 Bochum, Germany
来源：
MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 03期
基金：
英国惠康基金;
关键词：
2-Arylbenzothiazole; Piperazine; Fluorine; Antimicrobial; BENZOTHIAZOLE DERIVATIVES BEARING; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; ANTIBACTERIAL AGENTS; CRYSTAL-STRUCTURE; INHIBITORS; DISCOVERY;
D O I：
10.1007/s00706-017-2088-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 mu g/cm(3) compared to tamoxifen used as a positive standard. [GRAPHICS] .
引用
收藏
页码：645 / 651
页数：7
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