Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

被引：8

作者：

Al-Harthy, Thuraya ^{[1
]}

Zoghaib, Wajdi M. ^{[1
]}

Stoll, Raphael ^{[2
]}

Abdel-Jalil, Raid ^{[1
]}

机构：

[1] Sultan Qaboos Univ, Dept Chem, Coll Sci, Muscat, Oman

[2] Ruhr Univ Bochum, Biomol NMR, D-44780 Bochum, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 03期

基金：

英国惠康基金;

关键词：

2-Arylbenzothiazole; Piperazine; Fluorine; Antimicrobial; BENZOTHIAZOLE DERIVATIVES BEARING; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; ANTIBACTERIAL AGENTS; CRYSTAL-STRUCTURE; INHIBITORS; DISCOVERY;

D O I：

10.1007/s00706-017-2088-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 mu g/cm(3) compared to tamoxifen used as a positive standard. [GRAPHICS] .

引用

页码：645 / 651

页数：7

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