Anti-Mullerian hormone as an ovarian reserve marker in women with the most frequent muscular dystrophies

被引：4

作者：

Parmova, Olesja ^{[1
,2
,3
]}

Vlckova, Eva ^{[1
,2
,3
,4
]}

Hulova, Monika ^{[1
,2
]}

Mensova, Livie ^{[3
,5
,6
]}

Crha, Igor ^{[2
,7
]}

Stradalova, Petra ^{[1
,2
]}

Kralickova, Eva ^{[1
]}

Jurikova, Lenka ^{[2
,3
,8
,9
]}

Podborska, Martina ^{[10
]}

Mazanec, Radim ^{[3
,8
,9
]}

Dusek, Ladislav ^{[11
]}

Jarkovsky, Jiri ^{[11
]}

Bednarik, Josef ^{[1
,2
,3
,4
]}

Vohanka, Stanislav ^{[1
,2
,3
,4
]}

Srotova, Iva ^{[1
,2
,3
,4
]}

机构：

[1] Univ Hosp Brno, Dept Neurol, Jihlavska 20, Brno 62500, Czech Republic

[2] Masaryk Univ, Fac Med, Brno, Czech Republic

[3] European Reference Network Rare Neuromuscular Dis, Prague, Czech Republic

[4] Masaryk Univ, CEITEC Cent European Inst Technol, Brno, Czech Republic

[5] Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic

[6] Univ Hosp Motol, Prague, Czech Republic

[7] Univ Hosp Brno, Dept Obstet & Gynaecol, Brno, Czech Republic

[8] Masaryk Univ, Dept Paediat Neurol, Brno, Czech Republic

[9] Univ Hosp Brno, Brno, Czech Republic

[10] Univ Hosp Brno, Dept Clin Biochem, Brno, Czech Republic

[11] Masaryk Univ, Inst Biostat & Anal, Brno, Czech Republic

来源：

MEDICINE | 2020年 / 99卷 / 23期

关键词：

anti-Mullerian hormone; fertility; muscular dystrophy; myotonic dystrophy; ovarian reserve; MYOTONIC-DYSTROPHY; ANTIMULLERIAN HORMONE; FOLLICULAR STATUS; HEALTHY FEMALES; SERUM-LEVELS; STIMULATION; POPULATION; PREDICTION; ESTRADIOL; FSH;

D O I：

10.1097/MD.0000000000020523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Some muscular dystrophies may have a negative impact on fertility. A decreased ovarian reserve is 1 of the factors assumed to be involved in fertility impairment. AMH (anti-Mullerian hormone) is currently considered the best measure of ovarian reserve. A total of 21 females with myotonic dystrophy type 1 (MD1), 25 females with myotonic dystrophy type 2 (MD2), 12 females with facioscapulohumeral muscular dystrophy (FSHD), 12 female carriers of Duchenne muscular dystrophy mutations (cDMD) and 86 age-matched healthy controls of reproductive age (range 18 - 44 years) were included in this case control study. An enzymatically amplified 2-site immunoassay was used to measure serum AMH level. The MD1 group shows a significant decrease of AMH values (median 0.7ng/mL; range 0 - 4.9ng/mL) compared with age-matched healthy controls (P<.01). AMH levels were similar between patients and controls in terms of females with MD2 (P=.98), FSHD (P=.55) and cDMD (P=.60). This study suggests decreased ovarian reserve in women with MD1, but not in MD2, FSHD and cDMD.

引用

页数：6

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