Golgi complex fragmentation in G2/M transition: An organelle-based cell-cycle checkpoint

被引：45

作者：

Corda, Daniela ^{[1
]}

Barretta, Maria Luisa ^{[1
]}

Cervigni, Romina Ines ^{[1
]}

Colanzi, Antonino ^{[1
]}

机构：

[1] CNR, Inst Prot Biochem, I-80131 Naples, Italy

来源：

IUBMB LIFE | 2012年 / 64卷 / 08期

关键词：

Golgi ribbon; cell cycle; mitosis; membranes; organelles; CtBP1-S; BARS; GRASP-55; GRASP-65; POLO-LIKE KINASE-3; RIBBON FORMATION; AURORA-A; CISTERNAL STACKING; MAMMALIAN-CELLS; ARP2/3; COMPLEX; ACTIN DYNAMICS; PROTEIN; MITOSIS; GRASP65;

D O I：

10.1002/iub.1054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, the Golgi complex is organized into a continuous membranous system known as the Golgi ribbon, which is formed by individual Golgi stacks that are laterally connected by tubular bridges. During mitosis, the Golgi ribbon undergoes extensive fragmentation through a multistage process that is required for its correct partitioning into the daughter cells. Importantly, inhibition of this Golgi disassembly results in cell-cycle arrest at the G2 stage, suggesting that accurate inheritance of the Golgi complex is monitored by a Golgi mitotic checkpoint. Here, we discuss the mechanisms and regulation of the Golgi ribbon breakdown and briefly comment on how Golgi partitioning may inhibit G2/M transition. (c) 2012 IUBMB IUBMB Life, 64(8): 661670, 2012

引用

页码：661 / 670

页数：10

共 88 条

[1] Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis [J].