Dopaminergic function and progression of Parkinson's disease: PET findings

被引:16
作者
Biju, G. [1 ]
de la Fuente-Fernandez, R. [1 ]
机构
[1] Univ British Columbia, Pacific Parkinsons Res Ctr, Vancouver, BC, Canada
关键词
Dopamine; Parkinson's disease; Positron emission tomography; Progression;
D O I
10.1016/S1353-8020(09)70833-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent PET studies in Parkinson's disease (PD) have shown that the progression of neurodegeneration follows an exponential decay pattern. Most of the damage to the nigrostriatal dopamine system occurs during the presymptomatic phase of the disease and the first few years following symptomonset. The progressive loss of dopaminergic neurons is accompanied by several functional adaptive changes in surviving nerve terminals, which lead to increased dopamine turnover and raise the risk of treatment-related motor complications. Younger PD patients seem to have more efficient compensatory mechanisms and a slower rate of progression of neurodegeneration. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:S38 / S40
页数:3
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