Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid

被引:45
作者
Calomme, M
Geusens, P
Demeester, N
Behets, GJ
D'Haese, P
Sindambiwe, JB
Van Hoof, V
Vanden Berghe, D
机构
[1] Univ Antwerp, Dept Pharmaceut Sci, Fac Pharmaceut Biomed & Vet Sci, B-2610 Antwerp, Belgium
[2] Univ Hasselt, Biomed Res Inst, B-3590 Diepenbeek, Belgium
[3] Univ Hosp Maastricht, Dept Rheumatol, NL-6229 HX Maastricht, Netherlands
[4] Univ Antwerp, Fac Med, B-2610 Antwerp, Belgium
[5] Univ Antwerp Hosp, Dept Clin Chem, B-2650 Antwerp, Belgium
关键词
choline-stabilized orthosilicic acid; silicon; bone; bone mineral density; ovariectomy;
D O I
10.1007/s00223-005-0288-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Silicon (Si) deficiency in animals results in bone defects. Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements. The effect of ch-OSA supplementation was investigated on bone loss in aged ovariectomized (OVX) rats. Female Wistar rats (n = 58, age 9 months) were randomized in three groups. One group was sham-operated (sham, n = 21), and bilateral OVX was performed in the other two groups. OVX rats were supplemented orally with ch-OSA over 30 weeks (OVX1, n = 20; 1 mg Si/kg body weight daily) or used as controls (OVX0, n = 17). The serum Si concentration and the 24-hour urinary Si excretion of supplemented OVX rats was significantly higher compared to sham and OVX controls. Supplementation with ch-OSA significantly but partially reversed the decrease in Ca excretion, which was observed after OVX. The increase in bone turnover in OVX rats tended to be reduced by ch-OSA supplementation. ch-OSA supplementation increased significantly the femoral bone mineral content (BMC) in the distal region and total femoral BMC in OVX rats, whereas lumbar BMC was marginally increased. Femoral BMD was significantly increased at two sites in the distal region in OVX rats supplemented with ch-OSA compared to OVX controls. Total lumbar bone mineral density was marginally increased by ch-OSA supplementation. In conclusion, ch-OSA supplementation partially prevents femoral bone loss in the aged OVX rat model.
引用
收藏
页码:227 / 232
页数:6
相关论文
共 31 条
[1]   MECHANICAL-PROPERTIES, BONE-MINERAL CONTENT, AND BONE-COMPOSITION (COLLAGEN, OSTEOCALCIN, IGF-I) OF THE RAT FEMUR - INFLUENCE OF OVARIECTOMY AND NANDROLONE DECANOATE (ANABOLIC-STEROID) TREATMENT [J].
AERSSENS, J ;
VANAUDEKERCKE, R ;
GEUSENS, P ;
SCHOT, LPC ;
OSMAN, AAH ;
DEQUEKER, J .
CALCIFIED TISSUE INTERNATIONAL, 1993, 53 (04) :269-277
[2]   Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin [J].
Barel, A ;
Calomme, M ;
Timchenko, A ;
De Paepe, K ;
Demeester, N ;
Rogiers, V ;
Clarys, P ;
Vanden Berghe, D .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2005, 297 (04) :147-153
[3]  
Calomme M, 2000, TRACE ELEMENTS IN MAN AND ANIMALS 10, P1111
[4]  
Calomme M. R., 2002, Calcified Tissue International, V70, P292
[5]   Supplementation of calves with stabilized orthosilicic acid - Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage [J].
Calomme, MR ;
VandenBerghe, DA .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1997, 56 (02) :153-165
[6]   INVIVO REQUIREMENT FOR SILICON IN ARTICULAR-CARTILAGE AND CONNECTIVE-TISSUE FORMATION IN CHICK [J].
CARLISLE, EM .
JOURNAL OF NUTRITION, 1976, 106 (04) :478-484
[7]   SILICON . A POSSIBLE FACTOR IN BONE CALCIFICATION [J].
CARLISLE, EM .
SCIENCE, 1970, 167 (3916) :279-&
[8]   SHORT-TERM EFFECTS OF ORGANIC SILICON ON TRABECULAR BONE IN MATURE OVARIECTOMIZED RATS [J].
HOTT, M ;
DEPOLLAK, C ;
MODROWSKI, D ;
MARIE, PJ .
CALCIFIED TISSUE INTERNATIONAL, 1993, 53 (03) :174-179
[9]   Long-term changes in bone mineral and biomechanical properties of vertebrae and femur in aging, dietary calcium restricted, and/or estrogen-deprived/-replaced rats [J].
Jiang, YB ;
Zhao, HK ;
Genant, HK ;
Dequeker, J ;
Geusens, P .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (05) :820-831
[10]   Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort [J].
Jugdaohsingh, R ;
Tucker, KL ;
Qiao, N ;
Cupples, LA ;
Kiel, DP ;
Powell, JJ .
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (02) :297-307