HPTLC densitometric analysis of Orthosiphon stamineus leaf extracts and inhibitory effect on xanthine oxidase activity

被引：8

作者：

Akowuah, GA

Zhari, I

Sadikun, A

Norhayati, I

机构：

[1] Univ Coll Sedaya Int, Sch Pharm, Kuala Lumpur 56000, Malaysia

[2] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden, Panang, Malaysia

来源：

PHARMACEUTICAL BIOLOGY | 2006年 / 44卷 / 01期

关键词：

HPTLC; lipid peroxidation; Orthosiphon stamineus; sinensetin; xanthine oxidase;

D O I：

10.1080/13880200500531045

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Orthosiphon stamineus Benth. was cultivated at different locations in Malaysia to compare the xanthine oxidase inhibitory potential of the methanol extracts of the leaf. The extracts showed superoxide scavenging and xanthine oxidase inhibitory activities using in vitro methods. By means of HPTLC densitometric technique and UV-Vis spectra, sinensetin (SEN) and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (TMF) concentrations in the extracts were found to vary from 0.09% to 0.36% and 0.02% to 0.10% of the day weight, respectively. The study provided evidence that the leaf of the plant can be useful for studying its anti-gout action.

引用

页码：65 / 70

页数：6

共 15 条

[1] Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers [J].