Lower treatment intensity and poorer survival in metastatic colorectal cancer patients who live alone

被引：43

作者：

Cavalli-Bjorkman, N. ^{[1
]}

Qvortrup, C. ^{[2
]}

Sebjornsen, S. ^{[3
]}

Pfeiffer, P. ^{[2
]}

Wentzel-Larsen, T. ^{[4
,5
,6
]}

Glimelius, B. ^{[1
,7
]}

Sorbye, H. ^{[3
]}

机构：

[1] Uppsala Univ, Dept Radiol Oncol & Radiat Sci, S-75185 Uppsala, Sweden

[2] Odense Univ Hosp, Dept Oncol, DK-5000 Odense C, Denmark

[3] Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway

[4] Haukeland Hosp, Clin Res Ctr, N-5021 Bergen, Norway

[5] Eastern & So Norway, Ctr Child & Adolescent Mental Hlth, N-0484 Oslo, Norway

[6] Norwegian Ctr Violence & Traumat Stress Studies, N-0450 Oslo, Norway

[7] Karolinska Inst, Dept Oncol & Pathol, S-17177 Stockholm, Sweden

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 01期

关键词：

colorectal cancer; socioeconomic status; education; living alone; social support; comorbidity; III COLON-CANCER; SOCIOECONOMIC-STATUS; MARITAL-STATUS; RECTAL-CANCER; LUNG-CANCER; STAGE; IMPACT; INEQUALITIES; DISADVANTAGE; DEPRIVATION;

D O I：

10.1038/bjc.2012.186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Socioeconomic status (SES) and social support influences cancer survival. If SES and social support affects cancer treatment has not been thoroughly explored. METHODS: A cohort consisting of all patients who were initially diagnosed with or who developed metastatic colorectal cancer (mCRC, n = 781) in three Scandinavian university hospitals from October 2003 to August 2006 was set up. Clinical and socioeconomic data were registered prospectively. RESULTS: Patients living alone more often had synchronous metastases at presentation and were less often treated with combination chemotherapy than those cohabitating (HR 0.19, 95% CI 0.04-0.85, P = 0.03). Surgical removal of metastases was less common in patients living alone (HR 0.29, 95% CI 0.10-0.86, P = 0.02) but more common among university-educated patients (HR 2.22, 95% CI 1.10-4.49, P = 0.02). Smoking, being married and having children did not influence treatment or survival. Median survival was 7.7 months in patients living alone and 11.7 months in patients living with someone (P < 0.001). Living alone remained a prognostic factor for survival after correction for age and comorbidity. CONCLUSION: Patients living alone received less combination chemotherapy and less secondary surgery. Living alone is a strong independent risk factor for poor survival in mCRC. British Journal of Cancer (2012) 107, 189-194. doi:10.1038/bjc.2012.186 www.bjcancer.com Published online 10 May 2012 (C) 2012 Cancer Research UK

引用

页码：189 / 194

页数：6

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