Using Transcriptional Signatures to Assess Immune Cell Function: From Basic Mechanisms to Immune-Related Disease

被引：6

作者：

Touzot, Maxime ^{[1
,2
,4
]}

Dahirel, Alix ^{[1
,2
,4
]}

Cappuccio, Antonio ^{[1
,2
,3
,4
]}

Segura, Elodie ^{[1
,2
]}

Hupe, Philippe ^{[2
,3
,5
]}

Soumelis, Vassili ^{[1
,2
,4
]}

机构：

[1] INSERM, U932, F-75005 Paris, France

[2] Inst Curie, Sect Rech, F-75005 Paris, France

[3] Inst Curie, INSERM, U900, Serv Bioinformat, F-75248 Paris, France

[4] Inst Curie, Clin Immunol Lab, F-75005 Paris, France

[5] CNRS, UMR 144, F-75700 Paris, France

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2015年 / 427卷 / 21期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; BLOOD MONONUCLEAR-CELLS; KIDNEY-TRANSPLANT REJECTION; GENE-EXPRESSION; PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; INTERFERON SIGNATURE; I INTERFERON; CLINICAL-RESPONSE; ANALYSIS REVEALS;

D O I：

10.1016/j.jmb.2015.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assessing human immune response remains a challenge as it involves multiple cell types in specific tissues. The use of microarray-based expression profiling as a tool for assessing the immune response has grown increasingly over the past decade. Transcriptome analyses provide investigators with a global perspective of the complex molecular and cellular events that unfold during the development of an immune response. In this review, we will detail the broad use of gene expression profiling to decipher the complexity of immune responses from disease biomarkers identification to cell activation, polarisation or functional specialisation. We will also describe how such data-driven strategies revealed the flexibility of immune function with common and specific transcriptional programme under multiple stimuli. (C) 2015 Published by Elsevier Ltd.

引用

页码：3356 / 3367

页数：12

共 87 条

[1] Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse [J].

Achiron, Anat ;

Feldman, Anna ;

Mandel, Mathilda ;

Gurevich, Michael .

AUTOIMMUNITY, PT C: THE MOSAIC OF AUTOIMMUNITY, 2007, 1107 :155-167

[2] Leukocyte gene expression signatures in antineutrophil cytoplasmic autoantibody and lupus glomerulonephritis [J].

Alcorta, D. A. ;

Barnes, D. A. ;

Dooley, M. A. ;

Sullivan, P. ;

Jonas, B. ;

Liu, Y. ;

Lionaki, S. ;

Reddy, C. B. ;

Chin, H. ;

Dempsey, A. A. ;

Jennette, J. C. ;

Falk, R. J. .

KIDNEY INTERNATIONAL, 2007, 72 (07) :853-864

[3] Microarray-based identification of novel biomarkers in IL-1-mediated diseases [J].

Allantaz, Florence ;

Chaussabel, Damien ;

Banchereau, Jacques ;

Pascual, Virginia .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) :623-632

[4] Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade [J].

Allantaz, Florence ;

Chaussabel, Damien ;

Stichweh, Dorothee ;

Bennett, Lynda ;

Allman, Windy ;

Mejias, Asuncion ;

Ardura, Monica ;

Chung, Wendy ;

Wise, Carol ;

Palucka, Karolina ;

Ramilo, Octavio ;

Punaro, Marilynn ;

Banchereau, Jacques ;

Pascual, Virginia .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (09) :2131-2144

[5] Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C [J].

Asselah, T. ;

Bieche, I. ;

Narguet, S. ;

Sabbagh, A. ;

Laurendeau, I. ;

Ripault, M-P ;

Boyer, N. ;

Martinot-Peignoux, M. ;

Valla, D. ;

Vidaud, M. ;

Marcellin, P. .

GUT, 2008, 57 (04) :516-524

[6] Gene expression and hepatitis C virus infection [J].

Asselah, T. ;

Bieche, I. ;

Sabbagh, A. ;

Bedossa, P. ;

Moreau, R. ;

Valla, D. ;

Vidaud, M. ;

Marcellin, P. .

GUT, 2009, 58 (06) :846-858

[7] An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity [J].

Baechler, Emily C. ;

Bauer, Jason W. ;

Slattery, Catherine A. ;

Ortmann, Ward A. ;

Espe, Karl J. ;

Novitzke, Jill ;

Ytterberg, Steven R. ;

Gregersen, Peter K. ;

Behrens, Timothy W. ;

Reed, Ann M. .

MOLECULAR MEDICINE, 2007, 13 (1-2) :59-68

[8] Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells [J].

Balan, Sreekumar ;

Ollion, Vincent ;

Colletti, Nicholas ;

Chelbi, Rabie ;

Montanana-Sanchis, Frederic ;

Liu, Hong ;

Thien-Phong Vu Manh ;

Sanchez, Cindy ;

Savoret, Juliette ;

Perrot, Ivan ;

Doffin, Anne-Claire ;

Fossum, Even ;

Bechlian, Didier ;

Chabannon, Christian ;

Bogen, Bjarne ;

Asselin-Paturel, Carine ;

Shaw, Michael ;

Soos, Timothy ;

Caux, Christophe ;

Valladeau-Guilemond, Jenny ;

Dalod, Marc .

JOURNAL OF IMMUNOLOGY, 2014, 193 (04) :1622-1635

[9] Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines [J].

Banchereau, Romain ;

Baldwin, Nicole ;

Cepika, Alma-Martina ;

Athale, Shruti ;

Xue, Yaming ;

Yu, Chun I. ;

Metang, Patrick ;

Cheruku, Abhilasha ;

Berthier, Isabelle ;

Gayet, Ingrid ;

Wang, Yuanyuan ;

Ohouo, Marina ;

Snipes, LuAnn ;

Xu, Hui ;

Obermoser, Gerlinde ;

Blankenship, Derek ;

Oh, Sangkon ;

Ramilo, Octavio ;

Chaussabel, Damien ;

Banchereau, Jacques ;

Palucka, Karolina ;

Pascual, Virginia .

NATURE COMMUNICATIONS, 2014, 5

[10] Peripheral blood gene expression profiling in rheumatoid arthritis [J].

Batliwalla, FM ;

Baechler, EC ;

Xiao, X ;

Li, W ;

Balasubramanian, S ;

Khalili, H ;

Damle, A ;

Ortmann, W ;

Perrone, A ;

Kantor, AB ;

Gulko, PS ;

Kern, M ;

Furie, R ;

Behrens, TW ;

Gregersen, PK .

GENES AND IMMUNITY, 2005, 6 (05) :388-397

← 1 2 3 4 5 6 7 8 9 →