The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer

被引：13

作者：

Moehlendick, Birte ^{[1
]}

Schmid, Kurt W. ^{[2
]}

Siffert, Winfried ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Inst Pharmacogenet, Hufelandstr 55, D-45122 Essen, Germany

[2] Univ Duisburg Essen, Univ Hosp Essen, Inst Pathol, Hufelandstr 55, D-45122 Essen, Germany

来源：

PHARMACOGENOMICS | 2019年 / 20卷 / 07期

关键词：

cancer; FokI; GNAS; progression; rs7121; SNP; survival; T393C; therapy response; PROTEIN-COUPLED RECEPTORS; POLYMORPHISM PREDICTS SURVIVAL; SQUAMOUS-CELL CARCINOMA; G-ALPHA-S; T393C POLYMORPHISM; ADENYLYL-CYCLASE; DOWN-REGULATION; GENE GNAS1; ASSOCIATION; G(S)ALPHA;

D O I：

10.2217/pgs-2018-0199

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory G(s) subunit has been frequently associated with cancer. GNAS sequence alterations and conformational changes of G(s) can both enhance or diminish its function and change downstream effects of G-protein receptor signaling. In this review and meta-analysis, we focus on the synonymous SNP rs7121 (FokI, c.393C>T), which is associated with either tumor progression or prolonged survival in cancer patients (overall hazard ratio=2.256;p <0.001). We finally point out the relevance of GNAS rs7121 as a promising biomarker and a prediction tool for therapy response and the need of further experiments to implement it into routine clinical diagnostics.

引用

页码：553 / 562

页数：10

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The GNAS SNP c.393C&gt;T (rs7121) as a marker for disease progression and survival in cancer

The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer