Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy

被引：8

作者：

Aubert, Carole E. ^{[2
]}

Liabeuf, Sophie ^{[5
,6
,7
]}

Amouyal, Chloe ^{[1
,2
,11
]}

Kemel, Salim ^{[3
]}

Lajat-Kiss, Frederique ^{[4
]}

Lacorte, Jean-Marc ^{[1
,9
,11
,16
]}

Halbron, Marine ^{[2
,11
]}

Carlier, Aurelie ^{[1
,2
,11
]}

Salem, Joe-Elie ^{[1
,11
,12
,13
,14
]}

Funck-Brentano, Christian ^{[1
,11
,12
,13
,14
]}

Perisic Matic, Ljubica ^{[17
,18
]}

Witasp, Anna ^{[18
,19
]}

Stenvinkel, Peter ^{[19
]}

Phan, Franck ^{[1
,2
,11
]}

Massy, Ziad A. ^{[8
,15
]}

Hartemann, Agnes ^{[1
,2
,10
,11
]}

Bourron, Olivier ^{[1
,2
,10
,11
]}

机构：

[1] UPMC Univ, Sorbonne Univ, Paris 06, France

[2] Hop La Pitie Salpetriere, AP HP, Diabetol Dept, 47-83 Blvd Hop, Paris, France

[3] Hop La Pitie Salpetriere, AP HP, Cardiovasc & Intervent Radiol Dept, Paris, France

[4] Hop La Pitie Salpetriere, AP HP, Dept Vasc Surg, Paris, France

[5] Jules Verne Univ Picardy, UFR Med & Pharm, INSERM, U1088, Amiens, France

[6] Amiens Univ Hosp, Div Clin Pharmacol, Clin Res Ctr, Amiens, France

[7] Jules Verne Univ Picardy, Amiens, France

[8] Ambroise Pare Hosp, AP HP, Div Nephrol, Boulogne, France

[9] Hop La Pitie Salpetriere, AP HP, Dept Endocrine & Oncol Biochem, Paris, France

[10] Ctr Rech Cordeliers, INSERM, UMR S 1138, Paris 06, France

[11] ICAN, Paris, France

[12] Hop La Pitie Salpetriere, AP HP, Dept Pharmacol, Paris, France

[13] Hop La Pitie Salpetriere, AP HP, CIC 1421, Paris, France

[14] INSERM, CIC 1421, Paris, France

[15] Univ Paris Saclay Versailles St Quentin En Yvelin, INSERM, U1018, Res Ctr Epidemiol & Populat Hlth CESP,Team 5, Villejuif, France

[16] INSERM, U1166, Paris, France

[17] Karolinska Inst, Dept Mol Med & Surg, Div Vasc Surg, Stockholm, Sweden

[18] Karolinska Inst, Ctr Mol Med, Stockholm, Sweden

[19] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2019年 / 11卷 / 1期

关键词：

Vascular calcification; Adiponectin; Type; 2; diabetes; Peripheral arterial disease; KNEE ARTERIAL CALCIFICATION; CHRONIC KIDNEY-DISEASE; PROGNOSTIC VALUE; HEART; RISK; MUSCLE; RESISTANCE; MORTALITY; BONE;

D O I：

10.1186/s13098-019-0429-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundMedial calcification in diabetes contributes to the arterial occlusive process occurring below the knee level. Adiponectin is an adipokine with atheroprotective properties and possible protective role against arterial calcification. The aim of the study was to investigate, in type 2 diabetes, the link between vascular expression and serum concentration of adiponectin and (1) peripheral arterial calcification and (2) lower limb occlusive arterial disease.MethodsScoring of peripheral vascular calcification and peripheral arterial occlusive disease, using CT-scan and color-duplex ultrasonography respectively, were conducted and explored in relation to serum adiponectin level in a cross sectional study of 197 patients with type 2 diabetes. Vascular adiponectin expression in the arterial wall of diabetic patients with and without medial calcification was evaluated by immunohistochemistry.ResultsPeripheral arterial calcification score was higher in patients with the highest adiponectin concentration. In a multivariate logistic regression analysis, an increase of 1 mu g/mL of adiponectin was associated with a 22% increase of arterial calcification (adjusted OR=1.22; 95% CI 1.03-1.44; p=0.02). Arterial occlusive score was also higher in patients with adiponectin concentration>median (2.84.8 vs 4.25.7, p=0.034). Immunohistochemical analyses showed a strong and specific staining of adiponectin in smooth muscle cells in calcified arteries, with a more pronounced expression of adiponectin in early stages of medial calcification.ConclusionsPeripheral arterial calcification is positively associated with circulating adiponectin levels in patients with type 2 diabetes, but vascular adiponectin expression is already observed at early stages of calcification. Adiponectin secretion could be a compensatory mechanism against the calcification process.Trial registration DIACART NCT number: NCT02431234. Registered 30 April 2015

引用

页数：10

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