Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS

被引：73
作者：
Sergi, M. [1 ]
Bafile, E. [2 ]
Compagnone, D. [1 ]
Curini, R. [2 ]
D'Ascenzo, G. [2 ]
Romolo, F. S.
机构：
[1] Univ Teramo, Dept Food Sci, I-64023 Teramo, Italy
[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2009年 / 393卷 / 02期
关键词：
Abuse drugs; Liquid chromatography-tandem mass spectrometry; Plasma; Oral fluids; Forensic analytical chemistry; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE EXTRACTION; SURFACE-WATER; URINE; METABOLITES; ABUSE; COCAINE; IDENTIFICATION; AMPHETAMINES; METHAMPHETAMINE;
D O I：
10.1007/s00216-008-2456-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography-tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis.
引用
收藏
页码：709 / 718
页数：10
相关论文
共 54 条
[11]   Determination of illicit drugs and their metabolites in human urine by liquid chromatography tandem mass spectrometry including relative ion intensity criterion [J].
Concheiro, Marta ;
De Castro, Ana ;
Quintela, Oscar ;
Cruz, Angelines ;
Lopez-Rivadulla, Manuel .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2007, 31 (09) :573-580
[12]   Oral fluid collection: The neglected variable in oral fluid testing [J].
Crouch, DJ .
FORENSIC SCIENCE INTERNATIONAL, 2005, 150 (2-3) :165-173
[13]   Urine drug testing for opioids, cocaine, and metabolites by direct injection liquid chromatography/tandem mass spectrometry [J].
Dams, R ;
Murphy, CM ;
Lambert, WE ;
Huestis, MA .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (14) :1665-1670
[14]   Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry [J].
Deventer, K ;
Van Eenoo, P ;
Delbeke, FT .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (05) :877-882
[15]   Review: Pharmacokinetics of illicit drugs in oral fluid [J].
Drummer, OH .
FORENSIC SCIENCE INTERNATIONAL, 2005, 150 (2-3) :133-142
[16]   Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry [J].
Edwards, SR ;
Smith, MT .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 814 (02) :241-249
[17]   Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry [J].
Gheorghe, Adriana ;
van Nuijs, Alexander ;
Pecceu, Bert ;
Bervoets, Lieven ;
Jorens, Philippe G. ;
Blust, Ronny ;
Neels, Hugo ;
Covaci, Adrian .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (04) :1309-1319
[18]   Development of a liquid chromatography-tandem mass spectrometric method for the determination of methamphetamine and amphetamine using small volumes of rat serum [J].
Hendrickson, HP ;
Milesi-Hallé, A ;
Laurenzana, EM ;
Owens, SM .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 806 (02) :81-87
[19]   Legal issues in oral fluid testing [J].
Kadehjian, L .
FORENSIC SCIENCE INTERNATIONAL, 2005, 150 (2-3) :151-160
[20]   Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry [J].
Kasprzyk-Hordern, Barbara ;
Dinsdale, Richard M. ;
Guwy, Alan J. .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (04) :1293-1308
123456