Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS

被引：73

作者：

Sergi, M. ^{[1
]}

Bafile, E. ^{[2
]}

Compagnone, D. ^{[1
]}

Curini, R. ^{[2
]}

D'Ascenzo, G. ^{[2
]}

Romolo, F. S.

机构：

[1] Univ Teramo, Dept Food Sci, I-64023 Teramo, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2009年 / 393卷 / 02期

关键词：

Abuse drugs; Liquid chromatography-tandem mass spectrometry; Plasma; Oral fluids; Forensic analytical chemistry; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE EXTRACTION; SURFACE-WATER; URINE; METABOLITES; ABUSE; COCAINE; IDENTIFICATION; AMPHETAMINES; METHAMPHETAMINE;

D O I：

10.1007/s00216-008-2456-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography-tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis.

引用

页码：709 / 718

页数：10

共 54 条

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