Adjuvant treatment of colorectal cancer: Towards tumor-specific immunotherapies

被引：3
作者：
van den Eertwegh, AJM
Baars, A
Pinedo, HM
机构：
[1] Free Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands
[2] Free Univ Amsterdam, Med Ctr, Div Immunotherapy, NL-1081 HV Amsterdam, Netherlands
来源：
CANCER AND METASTASIS REVIEWS | 2001年 / 20卷 / 1-2期
关键词：
colorectal cancer; specific immunotherapy; adjuvant treatment;
D O I：
10.1023/A:1013160508133
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer is one of the leading causes of cancer-related mortality. After a series of clinical trials, the adjuvant 5-FU based chemotherapy has established a definitive role in the management of stage III colon cancer. The precise role for chemotherapy in stage II disease remains under investigation and less toxic treatment modalities like active specific immunotherapy have emerged as potentially attractive alternatives. It is most likely that the adjuvant treatment of colon cancer will move towards more tumor-specific immunotherapies using antibody- or vaccination-based strategies. Phase II/III clinical trials investigating these different modalities in colorectal cancer are reviewed.
引用
收藏
页码：101 / 108
页数：8
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