Adjuvant treatment of colorectal cancer: Towards tumor-specific immunotherapies

被引：3
作者：
van den Eertwegh, AJM
Baars, A
Pinedo, HM
机构：
[1] Free Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands
[2] Free Univ Amsterdam, Med Ctr, Div Immunotherapy, NL-1081 HV Amsterdam, Netherlands
来源：
CANCER AND METASTASIS REVIEWS | 2001年 / 20卷 / 1-2期
关键词：
colorectal cancer; specific immunotherapy; adjuvant treatment;
D O I：
10.1023/A:1013160508133
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer is one of the leading causes of cancer-related mortality. After a series of clinical trials, the adjuvant 5-FU based chemotherapy has established a definitive role in the management of stage III colon cancer. The precise role for chemotherapy in stage II disease remains under investigation and less toxic treatment modalities like active specific immunotherapy have emerged as potentially attractive alternatives. It is most likely that the adjuvant treatment of colon cancer will move towards more tumor-specific immunotherapies using antibody- or vaccination-based strategies. Phase II/III clinical trials investigating these different modalities in colorectal cancer are reviewed.
引用
收藏
页码：101 / 108
页数：8
相关论文
共 50 条
[11]   Role of tumor-specific and whole-body imaging biomarkers for prediction of recurrence in patients with stage III colorectal cancer [J].
Borhani, Amir A. ;
Zhang, Peng ;
Diergaarde, Brenda ;
Darwiche, Sophie ;
Chuperlovska, Kalina ;
Wang, Stewart C. ;
Schoen, Robert E. ;
Su, Grace L. .
ABDOMINAL RADIOLOGY, 2025, 50 (05) :1907-1915
[12]   Circulating Tumor DNA: Towards More Individualized Treatment for Patients with Resectable Colorectal Cancer [J].
Adams, Alexandra M. ;
Vreeland, Timothy J. ;
Newhook, Timothy E. .
JOURNAL OF GASTROINTESTINAL CANCER, 2023, 54 (04) :1071-1081
[13]   Circulating Tumor DNA: Towards More Individualized Treatment for Patients with Resectable Colorectal Cancer [J].
Alexandra M. Adams ;
Timothy J. Vreeland ;
Timothy E. Newhook .
Journal of Gastrointestinal Cancer, 2023, 54 :1071-1081
[14]   Consensus conference on adjuvant and palliative treatment of colorectal cancer [J].
Rodenburg, CJ ;
Willemse, PHB ;
Mulder, NH .
NETHERLANDS JOURNAL OF MEDICINE, 2000, 57 (02) :50-57
[15]   SEOM clinical guidelines for the adjuvant treatment of colorectal cancer [J].
Cristina Grávalos Castro ;
Joan Maurel Santasusana ;
Fernando Rivera Herrero ;
Ramón Salazar Soler ;
Isabel Sevilla García ;
Javier Sastre Valera ;
José M. Tabernero Caturla ;
Encarnación González Flores ;
María Lomas Garrido ;
Dolores Isla Casado .
Clinical and Translational Oncology, 2010, 12 :724-728
[16]   SEOM clinical guidelines for the adjuvant treatment of colorectal cancer [J].
Gravalos Castro, Cristina ;
Maurel Santasusana, Joan ;
Rivera Herrero, Fernando ;
Salazar Soler, Ramon ;
Sevilla Garcia, Isabel ;
Sastre Valera, Javier ;
Tabernero Caturla, Jose M. ;
Gonzalez Flores, Encarnacion ;
Lomas Garrido, Maria ;
Isla Casado, Dolores .
CLINICAL & TRANSLATIONAL ONCOLOGY, 2010, 12 (11) :724-728
[17]   Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters [J].
Montano-Samaniego, Mariela ;
Bravo-Estupinan, Diana M. ;
Mendez-Guerrero, Oscar ;
Alarcon-Hernandez, Ernesto ;
Ibanez-Hernandez, Miguel .
FRONTIERS IN ONCOLOGY, 2020, 10
[18]   The colorectal cancer immune microenvironment and approach to immunotherapies [J].
Koi, Minoru ;
Carethers, John M. .
FUTURE ONCOLOGY, 2017, 13 (18) :1633-1647
[19]   Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer [J].
Flebbe, Hannah ;
Hamdan, Feda H. ;
Kari, Vijayalakshmi ;
Kitz, Julia ;
Gaedcke, Jochen ;
Ghadimi, B. Michael ;
Johnsen, Steven A. ;
Grade, Marian .
CANCERS, 2019, 11 (08)
[20]   Outcome of Tumor-Specific Mesorectal Excision for Rectal Cancer: The Impact of Laparoscopic Resection [J].
Mohamed, Zakir K. ;
Law, Wai Lun .
WORLD JOURNAL OF SURGERY, 2014, 38 (08) :2168-2174
12345