Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patients

被引：12

作者：

Peralta, Raul ^{[1
]}

Valdivia, Alejandra ^{[1
]}

Estanol, Perla ^{[1
]}

Villegas, Vanessa ^{[1
]}

Pimienta, Carolina ^{[2
]}

Trevino, Eugenio ^{[2
]}

Marrero, Daniel ^{[3
]}

Mendoza, Monica ^{[1
]}

Jimenez, Florinda ^{[3
]}

Villalvazo, Leonardo ^{[4
]}

Tejeda, Miriam ^{[5
]}

Salcedo, Mauricio ^{[1
]}

机构：

[1] Hosp Oncol, Lab Oncogenom, UIMEO, IMSS,CMN SXXI, Mexico City 06720, DF, Mexico

[2] Fdn Hosp Nuestra Senora de la Luz IAP Ezequiel Mo, Serv Oftalmol, Mexico City 06030, DF, Mexico

[3] Univ Autonoma Ciudad Juarez, Lab Genom Func, Cd Juarez 32310, Chihuahua, Mexico

[4] Fdn Conde Valenciana, Dept Patol, Inst Oftalmol, Mexico City 06800, DF, Mexico

[5] Fdn Conde Valenciana, Dept Orbita, Inst Oftalmol, Mexico City 06800, DF, Mexico

来源：

INFECTIOUS AGENTS AND CANCER | 2011年 / 6卷

关键词：

conjunctiva; carcinoma; HPV; RISK-FACTORS; P53; GENE; NEOPLASIA; VIRUS; EXPRESSION; BENIGN; DNA;

D O I：

10.1186/1750-9378-6-24

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The relationship between Human Papillomavirus (HPV) infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in the biology of conjunctiva cancer. In the present study, DNA extracted and purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for HPV DNA sequences. The results were correlated with the clinical and histopathological variables. Results: The results showed that HPV DNA was present in 8 CSCC samples (22%); HPV16 was the sole type detected. Significant association was found between HPV detection and the limbus tumor subtype (p = 0.03). All the samples were non-metastatic squamous cell carcinoma. Conclusions: The HPV presence in CSCC from Mexican patients is not a common event.

引用

页数：5

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