The solute carrier 6 family of transporters

被引：181
作者：
Broeer, Stefan [1 ]
Gether, Ulrik [2 ]
机构：
[1] Australian Natl Univ, Res Sch Biol, Canberra, ACT 0200, Australia
[2] Univ Copenhagen, Panum Inst, Fac Hlth Sci, Mol Neuropharmacol Grp,Dept Neurosc & Pharmacol, Copenhagen, Denmark
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 167卷 / 02期
关键词：
monoamine transporters; antidepressants; transport mechanism; transporter pharmacology; AMINOBUTYRIC-ACID TRANSPORTER; HUMAN DOPAMINE TRANSPORTER; DEFICIT HYPERACTIVITY DISORDER; HUMAN SEROTONIN TRANSPORTER; HUMAN NORADRENALINE TRANSPORTER; INDUCED REVERSE TRANSPORT; HIGH-AFFINITY RECOGNITION; L-PROLINE TRANSPORTER; GLYCINE TRANSPORTER; NEUROTRANSMITTER TRANSPORTERS;
D O I：
10.1111/j.1476-5381.2012.01975.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters. LINKED ARTICLES BJP published a themed section on Transporters in 2011. To view articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.2011.164.issue-7/issuetoc
引用
收藏
页码：256 / 278
页数：23
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