Oxidative Palladium(II)-Catalyzed Dehydrogenative CH/CH Cross-Coupling of 2,3-Substituted Indolines with Arenes at the C7 Position

Directed directing group: The C7 position of the indoline nucleus is difficult to address in C-H activation. An oxidative palladium(II) catalysis that allows for cross-dehydrogenative coupling in that position with activation of the C-H bond of the arene component is disclosed here. This C-H/C-H cross-coupling is applicable to various indolines acetylated at the nitrogen atom. Substitution at C2 is crucial for the C-H activation to occur at C7 (see scheme). © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.