Biscembranoids from the Marine Sponge Petrosia nigricans

被引：0

作者：

Nguyen Xuan Nhiem ^{[1
]}

Ngo Van Quang ^{[2
]}

Chau Van Minh ^{[1
]}

Dan Thi Thuy Hang ^{[1
]}

Hoang Le Tuan Anh ^{[1
]}

Bui Huu Tai ^{[1
]}

Pham Hai Yen ^{[1
]}

Nguyen Thi Hoai ^{[3
]}

Do Cong Thung ^{[4
]}

Phan Van Kiem ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[2] VAST, Inst Chem, Hanoi, Vietnam

[3] Hue Univ Pharm & Med, Fac Pharm, Hue, Vietnam

[4] VAST, Inst Marine Resources & Environm, Ngo Quyen, Haiphong, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 09期

关键词：

Petrosia nigricans; Marine sponge; Petronigrione; Biscembranoid; Cytotoxic activity; CORAL LOBOPHYTUM-PAUCIFLORUM; POLYHYDROXYSTEROLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new biscembranoid, petronigrione (1), and five known compounds, methyl tortuoate B (2), lobophytone U (3), lobophytone H (4), (24,3)ergostane 3 beta,5 alpha,6 beta,25tetraol-25-monoacetate (5), and (24S)-ergostane-1 beta,3 beta,5 alpha,6 beta,25-pentaol-25-monoacetate (6), were isolated from the methanol extract of the marine sponge Petrosia nigricans. Their structures were established on the basis of spectral and chemical evidence. The cytotoxicity of all compounds was evaluated by MTT assay on four human cancer cell lines, HepG2, KB, LU-1, and MCF-7. Compounds 1 and 2 exhibited moderate cytotoxic activities on the four human cancer cell lines with IC50 values ranging of 20.7 - 28.9 mu g/mL.

引用

页码：1209 / 1212

页数：4

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