Accelerating the Translation of Nanomaterials in Biomedicine

被引：262

作者：

Mitragotri, Samir ^{[1
]}

Anderson, Daniel G. ^{[2
]}

Chen, Xiaoyuan ^{[3
]}

Chow, Edward K. ^{[4
]}

Ho, Dean ^{[5
]}

Kabanov, Alexander V. ^{[6
,7
]}

Karp, Jeffrey M. ^{[8
]}

Kataoka, Kazunori ^{[9
,10
]}

Mirkin, Chad A. ^{[11
,12
]}

Petrosko, Sarah Hurst ^{[11
,12
]}

Shi, Jinjun ^{[13
]}

Stevens, Molly M. ^{[14
]}

Sun, Shouheng ^{[15
]}

Teoh, Sweehin ^{[16
]}

Venkatraman, Subbu S. ^{[17
]}

Xia, Younan ^{[18
,19
]}

Wang, Shutao ^{[20
]}

Gu, Zhen ^{[21
,22
,23
,24
,25
]}

Xu, Chenjie ^{[16
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem Engn, Ctr Bioengn, Santa Barbara, CA 93106 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] NIH, Natl Inst Biomed Imaging & Bioengn, Bethesda, MD 20892 USA

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Canc Sci Inst Singapore, Singapore 119077, Singapore

[5] UCLA, Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90095 USA

[6] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[7] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

[8] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[9] Univ Tokyo, Dept Mat Engn, Tokyo 1138654, Japan

[10] Univ Tokyo, Dept Bioengn, Tokyo 1138654, Japan

[11] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[12] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA

[13] Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanoengn & Drug Delivery,Dept Anesthesiol, Boston, MA 02115 USA

[14] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, Dept Bioengn, Dept Mat, London SW7 2AZ, England

[15] Brown Univ, Dept Chem, Providence, RI 02912 USA

[16] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 639798, Singapore

[17] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[18] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA

[19] Emory Univ, Atlanta, GA 30322 USA

[20] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[21] Univ N Carolina, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[22] N Carolina State Univ, Raleigh, NC 27695 USA

[23] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[24] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

[25] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27695 USA

来源：

ACS NANO | 2015年 / 9卷 / 07期

关键词：

SIRNA DELIVERY; DRUG-DELIVERY; POLYMERIC MICELLES; ULTRASENSITIVE DETECTION; ELECTROSPUN NANOFIBERS; TUMOR-CELLS; NANOPARTICLES; NANOMEDICINE; RELEASE; NANO;

D O I：

10.1021/acsnano.5b03569

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to their size and tailorable physicochemical properties, nanomaterials are an emerging class of structures utilized in biomedical applications. There are now many prominent examples of nanomaterials being used to improve human health, in areas ranging from imaging and diagnostics to therapeutics and regenerative medicine. An overview of these examples reveals several common areas of synergy and future challenges. This Nano Focus discusses the current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic, by highlighting a handful of successful examples.

引用

页码：6644 / 6654

页数：11

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