The selective effect of plasma activated medium in an in vitro co-culture of liver cancer and normal cells

被引：74
作者：
Duan, J. [1 ]
Lu, X. [1 ,2 ]
He, G. [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Sch Elect & Elect Engn, State Key Lab Adv Electromagnet Engn & Technol, Wuhan, Peoples R China
[2] Shanghai Jiao Tong Univ, IFSA Collaborat Innovat Ctr, Shanghai 200240, Peoples R China
[3] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Chinese Minist Sci & Technol,Chinese Minist Educ, Genet Engn Int Cooperat Base,Key Lab Mol Biophys, Wuhan, Peoples R China
来源：
JOURNAL OF APPLIED PHYSICS | 2017年 / 121卷 / 01期
基金：
中国国家自然科学基金;
关键词：
DIELECTRIC BARRIER DISCHARGE; ATMOSPHERIC-PRESSURE PLASMA; NONTHERMAL PLASMA; OXIDATIVE STRESS; CARCINOMA-CELLS; MEDICINE; DEATH; THERAPY; STERILIZATION; STRATEGY;
D O I：
10.1063/1.4973484
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
In this work, a co-culture system with liver cancer cell line HepG2 and normal cell line L02 is used to investigate the selective effect on cancer and normal cells by plasma activated medium (PAM), which is closer to the real environment where cancer cells develop. Besides, the co-culture system is a better model to study the selective effect than the widely used separate culture systems, where the cancer cell line and normal cell line are cultured independently. By using the co-culture system, it is found that there is an optimum dose of PAM to induce significant cancer cell apoptosis while keeping minimum damage to normal cells. Published by AIP Publishing.
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页数：6
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